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Sofosbuvir/Ribavirin Side Effects

I am waiting for the SOF/RIBA combo therapy to be available and have not been able to find much info on the side effects experienced by those who have done the 12 week treatment. Most of what I find about RIBA sides has to do with it in combination with peginterferon. Anyone out there who has done this combo in trials who could share their experience?

Thanks!
25 Responses
Avatar universal
Hi,
They are still collecting data on the effects but according to the posts here there are few if any side effects for a person who is relatively healthy apary from having HCV.
I experienced some digestive upsets,insomnia and headaches, irritability, and a bit of a rash but most of my real discomfort was a result of extra hepatic manifestations due to HCV and cirrhosis.
Most people feel irritable on the ribavirin but again the degree of 'riba rage' depends on the individual. My Dr. told me that almost all the people in my study complained of some side effects but that overall (nationwide) the reports were that sx were minimal.
Of course compared to SOC, it is a cakewalk.
All the best :)
Avatar universal
  My husband is on a combo which includes Riba and Abbott333, Abt450 and Abt267, along with Ritonivir, and I noticed his HGB has dropped a point, although he is not anemic (less then 10) yet. He is a bit dizzy and sometimes a bit nauseous, and irritable, but the good news is, these treatments are only 12 weeks.
Avatar universal
my fam.doc just stated today that to expect side effects probably not as bad as interferon but not to think this as a wonderdrug til all research comes out.he was kind of avoiding my question on this manner today,i had asked @last appt.to study sof/riba combo.he's still very negative towards this treatment cause he said it really gets ppl.'s hopes up.but i am like you-i want to know more.his experience is 12 years at VA hospital workin w/ HCV pts.
i would like to know what research is being done w/ high iron pts.i cannot find nothing at all.
Avatar universal
What genotype are you?  
If you are type 1 you may want to wait for the sofosbuvir/ gs-5885 (or other NS5A) combo.

Avatar universal
I am a genotype 2b so I am looking at the sofo/riba combo without interferon due in 6 months or so
446474 tn?1446351282
Side effects from sofosbuvir and ribavirin treatment are listed in the top line results of the clinical trials.

"In FISSION (Genotype 2/3 treatment-naïve), just 1% of patients receiving 12 weeks of sofosbuvir plus ribavirin discontinued therapy. However, a higher rate — 11% — of patients who received 24 weeks of peginterferon plus ribavirin stopped treatment."

"In the second study, known as the FUSION trial, patients who had not had a response to prior interferon therapy received sofosbuvir and ribavirin for 12 or 16 weeks. The most common adverse events were again headache, fatigue, nausea, and insomnia, but the overall discontinuation rate was low at 1% to 2%.

Hector
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