Life-threatening complications in the later stages of hepatitis B and C are common in human patients, but such symptoms never occur in chimpanzees.
The human immunodeficiency virus often leads to AIDS in humans, while there are only a few cases in which HIV in chimpanzees develops into AIDS. And chimpanzees never get Alzheimer's disease, even in old age.
After close comparisons were made between humans and chimpanzees on 7,000 genes related to biological functions, the team found that humans have an additional 840,000 gene deletions and insertions in genetic sequencing, which may lead to the development of the diseases.
Gene deletions and insertions are very similar in the analogy of a word, for example "vocabulary," that is spelled correctly as "vocabulary" in the chimpanzee genetic sequence, but spelled "vocbulary" or "vocaebulary" in humans, Chen explained.
Chen noted these deletions and insertions may alter the expression of genes and interfere with the functions of RNA and protein, thus creating an environment in which certain human-specific diseases develop.
Yes, I always wondered about it ... especially when I worked at the cancer research lab and we were injecting little rats with cancer producing pathogens
Every drug that is a prescription, or has ever been a prescription, is tested at some point. We could go back to the wagon days on the frontier and have no testing if that would make everybody feel better! I for one, think that it's a good that there are people willing to be guinea pigs for new drugs. This is why I've signed up for the clinical trial for Teleprevir (Vertex drug). I don't know if I'll be picked yet. I've just completed the screening blood work. Everything is back on my labs except the viral load and genotype. All of my labs so far have met the trial standards.
Good luck, Susan, with your trial! You are a fighter and I wish you all the best!!!