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446474 tn?1446351282

Started GS 7977 & Ribavirin Trial

Hi all!

I started my HCV clinical trial treatment yesterday.

'An Open-Label Study to Explore the Clinical Efficacy of GS 7977 With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant'

Primary Outcome Measures:
Determination of post-transplant virological response [ Time Frame: 36 Weeks ] [ Designated as safety issue: No ]
To determine if the administration of a combination of GS 7977 and ribavirin to HCV-infected subjects with hepatocellular carcinoma (HCC) meeting the MILAN criteria prior to undergoing liver transplantation for up to 24 weeks can prevent post-transplant re-infection as determined by a sustained post-transplant virological response (HCV RNA <LLoQ) at 12 weeks post-transplant.

Treatment Drugs:

2 200 mg of GS-7977 in morning
3 200 mg of Ribavirin in morning
3 200 mg of Ribavirin at night (12 hours later)

But I am now on treatment and will continue for 24 weeks or transplant, which ever comes first.

I stopped my TB treatment today. I will deal with TB after transplant.
I just had a cancer screen MRI/AFP and I am waiting for the results...

I can't believe that within 4 weeks I will have no viral load for the first time in 42 years!!! Once I become undetectable I will be looking for a transplant. This treatment is my best shot at curing my hepatitis C as a previous null-responder.

I heard through the grapevine that a trial with GS-7977 will be starting for post-transplant patients who are infected with hepatitis C. The cure rate now is only 30% using peg-interferon and ribavirin. Very poor results so we need more options.

Happy- :-))
68 Responses
131114 tn?1380086790
i was just thinking about you!!!
i going next wed. for my plan.
can't wait to hear how you do.
i hope it all goes your way.
love jerialice
Avatar universal

This all sounds so positive! I have everything crossed for you!
Curious what geno type are you?
I will be watching for your posts.
GOOD LUCK Happy Hector !!!!

1815939 tn?1377995399
Hector, this is fabulous news. I am so happy for you. Wishing you the very best and SVR.
Avatar universal
So great to see this!!!

I'm happy for you and the many who may well follow in your footsteps if this works well.

I know it is not risk free but it seems a better choice to me than waiting.

One small step for Hector, one great step........ etc.  : )

446474 tn?1446351282
I am genotype 1b.

901131 tn?1293748153
Great news Hector!! Good luck and smooth sailing.
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