Started GS 7977 & Ribavirin Trial

[HectorSF]

Hi all!

I started my HCV clinical trial treatment yesterday.

'An Open-Label Study to Explore the Clinical Efficacy of GS 7977 With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant'
NCT01559844

Primary Outcome Measures:
Determination of post-transplant virological response [ Time Frame: 36 Weeks ] [ Designated as safety issue: No ]
To determine if the administration of a combination of GS 7977 and ribavirin to HCV-infected subjects with hepatocellular carcinoma (HCC) meeting the MILAN criteria prior to undergoing liver transplantation for up to 24 weeks can prevent post-transplant re-infection as determined by a sustained post-transplant virological response (HCV RNA <LLoQ) at 12 weeks post-transplant.

Treatment Drugs:

2 200 mg of GS-7977 in morning
3 200 mg of Ribavirin in morning
3 200 mg of Ribavirin at night (12 hours later)


But I am now on treatment and will continue for 24 weeks or transplant, which ever comes first.

I stopped my TB treatment today. I will deal with TB after transplant.
I just had a cancer screen MRI/AFP and I am waiting for the results...

I can't believe that within 4 weeks I will have no viral load for the first time in 42 years!!! Once I become undetectable I will be looking for a transplant. This treatment is my best shot at curing my hepatitis C as a previous null-responder.

I heard through the grapevine that a trial with GS-7977 will be starting for post-transplant patients who are infected with hepatitis C. The cure rate now is only 30% using peg-interferon and ribavirin. Very poor results so we need more options.

Happy- :-))
Hector

[ahk252]

hello ...
I asked a question about liver biopsy and its interpretation.
I want you to know, Is treatment with interferon and ribavirin is useful?
and what about 7977 with ribavirin outcome?
I'm from Egypt, Note that the type widespread in Egypt is genotype 4 ..
If you have any info about 7977,,,, When will deliberate and come to Egypt?

[ahk252]

Good luck Hector ...

[rockymoe]

Such wonderful news, they are doing that trial at Lahey in Boston. I'm waiting for round 9. I am angry and I am going to Slay This Dragon if it the last thing I do. My thoughts and prayers are with you!

[kmatucson]

  Woo hoo!! You go Hector!!  

[aGirl7977]

Super news! I wii keep you and everyone in my prayers!
I also heard there is a post transplant in the near future!  It is a great day for us all! Best Wishes & Blessings

[uncledudeness]

how did i miss this thread? If anyone here deserves a successful outcome it is you my friend. you have helped so many members over the years. i am so happy to read this thread....you will be successful....the best of luck.

[beeblessed]

I have missed so many posts and am just seeing this today.  Very happy for you my friend :0)

Hugs,
Bee

[Diamando6]

Dear Hector, good luck to you, I hope , this time it will work for you!

[jerialice]

Happy Hugs today! Be Well!
jerialice

[copyman]

That is great! I'm happy for you Hector.  

You have helped so many people on this forum you deserve this chance.

Wishing you the best in the coming weeks.

God Bless

[LookingForward12]

Ill be cheering you on as well! Thank goodness your doctor is so proactive and obviously determined to find the best trial for you!

Cheers.

[yodennis]

Your post was like a big smile with whipped cream on it. Congratulations on your possibilities my friend! d

[his3707]

Tootin the horn over here!!  

[frijole]

I am so happy to see this news, hector.  I have been thinking about you a lot as we approach 9/11.  I am glad the TB treatment was successful enough for you to stop to do tx and tp.  How often are they going to test your viral load?  How sensitive the test?  I don't remember that you have alive donor lined up, so does that just mean you have to wait until they call your number.  Hector, the success of all of this combined is going to do immense things for the Hep C community.  Thank you for including us.
bean

[jules2551]

Wishing you the very best Hector!

Jules

[flcyclist]

A little late, but just noticed this fantastic news!!  So great to hear Hector.  Puts a big smile on my face.  Wishing you the best of luck for a successful tx.   You have a ton of people on this forum sending you positive wishes.  Best of luck my friend.  

[Susan_1a_CC]

I do believe that your positive attitude will aid you.  I also believe that the good wishes and prayers of everyone here will aid you.  My wish is that this journey you are on be as easy as possible for you.  With deep respect I keep you in my thoughts,
Susan

[Gerbils]

I am praying that you will be blessed in your new efforts. I and everyone on here will be thrilled to see you succeed. It is absolutely awesome that you have this opportunity to fight on. Best of luck to you and GO HECTOR!!
G

[Dee1956]

This is the best news I have heard in a very long time
As usual I am day late dollar short Dee however my best wishes for you are all the more sincere.
As Hawk said, we are all rooting for you
You have been here for everyone on this forum.  We are all here for you
Godspeed my friend
Love
Dee

[jerialice]

here's your CHEER for today! yay, thinking about you and all the healthy cells collaborating!

[lapis]

GO Hector--GO Hector--GO Hector!!!

In my best cheerleader style, I'm cheering you on from the East Coast!!!  Happy and excited for you, big hugs!!  Really glad I checked in today...

Lapis

[scherpie]

Hoi, Hector,
I sent you some possitief energie from Holland. You are such a nice person. I hope that you wil come easy throught the next 6 months en become quickly virusfree. And that the new door opens in your life now.
Love Scherpie

[jerialice]

Hector coming on to join the group prayer and hug for the day!
I am going to try to get here everyday and send these off to you.
it's day one and you did it for today!!
you make us strong!
jerialice

(((*)))
/^\

[grizwald]

Hector,

I hope the best to you and I'm sure everything will work out the way you plan, it's just a matter of time.  You and your doctors will be in my prayers.  Take care and  get well soon.

Griz