Started GS 7977 & Ribavirin Trial

[HectorSF]

Hi all!

I started my HCV clinical trial treatment yesterday.

'An Open-Label Study to Explore the Clinical Efficacy of GS 7977 With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant'
NCT01559844

Primary Outcome Measures:
Determination of post-transplant virological response [ Time Frame: 36 Weeks ] [ Designated as safety issue: No ]
To determine if the administration of a combination of GS 7977 and ribavirin to HCV-infected subjects with hepatocellular carcinoma (HCC) meeting the MILAN criteria prior to undergoing liver transplantation for up to 24 weeks can prevent post-transplant re-infection as determined by a sustained post-transplant virological response (HCV RNA <LLoQ) at 12 weeks post-transplant.

Treatment Drugs:

2 200 mg of GS-7977 in morning
3 200 mg of Ribavirin in morning
3 200 mg of Ribavirin at night (12 hours later)


But I am now on treatment and will continue for 24 weeks or transplant, which ever comes first.

I stopped my TB treatment today. I will deal with TB after transplant.
I just had a cancer screen MRI/AFP and I am waiting for the results...

I can't believe that within 4 weeks I will have no viral load for the first time in 42 years!!! Once I become undetectable I will be looking for a transplant. This treatment is my best shot at curing my hepatitis C as a previous null-responder.

I heard through the grapevine that a trial with GS-7977 will be starting for post-transplant patients who are infected with hepatitis C. The cure rate now is only 30% using peg-interferon and ribavirin. Very poor results so we need more options.

Happy- :-))
Hector

[his3707]

Tootin the horn over here!!  

[frijole]

I am so happy to see this news, hector.  I have been thinking about you a lot as we approach 9/11.  I am glad the TB treatment was successful enough for you to stop to do tx and tp.  How often are they going to test your viral load?  How sensitive the test?  I don't remember that you have alive donor lined up, so does that just mean you have to wait until they call your number.  Hector, the success of all of this combined is going to do immense things for the Hep C community.  Thank you for including us.
bean

[jules2551]

Wishing you the very best Hector!

Jules

[flcyclist]

A little late, but just noticed this fantastic news!!  So great to hear Hector.  Puts a big smile on my face.  Wishing you the best of luck for a successful tx.   You have a ton of people on this forum sending you positive wishes.  Best of luck my friend.  

[Susan_1a_CC]

I do believe that your positive attitude will aid you.  I also believe that the good wishes and prayers of everyone here will aid you.  My wish is that this journey you are on be as easy as possible for you.  With deep respect I keep you in my thoughts,
Susan

[Gerbils]

I am praying that you will be blessed in your new efforts. I and everyone on here will be thrilled to see you succeed. It is absolutely awesome that you have this opportunity to fight on. Best of luck to you and GO HECTOR!!
G