Aa
Aa
A
A
A
Close
148588 tn?1465778809

Telaprevir Demonstrates Antiviral Activity in Genotype 2 Not Genotype 3 HCV

http://www.clinicaloptions.com/Hepatitis/Journal%20Options/Collections/2011%20JO%20Hepatitis%20Volume%205/Articles/Foster_Gastroenterology_2011/Slideset.aspx
2 Responses
Sort by: Helpful Oldest Newest
Avatar universal
Hi desrt, this was on the expert commentary part... Hope all is well.

Use of Telaprevir in Genotype 2 or 3 HCV—Not Likely
Mitchell L. Shiffman, MD
Posting Date: December 13, 2011
Director, Liver Institute of Virginia
Bon Secours Virginia Health System
Richmond and Newport News, Virginia

Telaprevir works very effectively against hepatitis C virus (HCV) genotype 1 infection, and a wealth of data support this fact.[1-5] By contrast, there are very few data about the efficacy of telaprevir in HCV genotypes 2 and 3, particularly in combination with peginterferon/ribavirin.

To shed light on this issue, Foster and colleagues[6] conducted a randomized phase IIa study in patients chronically infected with HCV genotype 2 or 3 to determine whether the addition of telaprevir to peginterferon/ribavirin enhanced the rates of sustained virologic response (SVR).[6] In total, 26 patients with HCV genotype 2 (23 were treated) and 26 patients with HCV genotype 3 infection were randomly assigned to receive 15 days of telaprevir, telaprevir plus peginterferon/ribavirin, or peginterferon/ribavirin, all followed by peginterferon/ribavirin for 22-24 weeks.

Unfortunately, the results of this study were somewhat disappointing. There was additive efficacy with telaprevir in patients with HCV genotype 2 infection. For example, the kinetics of virologic suppression occurred earlier and was deeper with the addition of telaprevir to peginterferon/ribavirin vs peginterferon/ribavirin alone (eg, median HCV RNA change at Day 3: -4.03 vs -2.04 log10 IU/mL; median HCV RNA change at Day 15: -5.51 vs -4.83 log10 IU/mL). All 5 patients who received telaprevir/peginterferon/ribavirin triple therapy attained SVR compared with 8 of 9 patients assigned to peginterferon/ribavirin control (100% vs 89%). One must recognize, however, that infection with HCV genotype 2 has the highest cure rate of all HCV genotypes when treated with peginterferon/ribavirin. Thus, despite having some antiviral activity against this type of HCV, the addition of telaprevir to peginterferon/ribavirin really has very little impact on overall SVR in this patient population.

Helpful - 0
163305 tn?1333668571
I couldn't bring the link up but as a geno 2, I'm glad not to be doing teleprivir.
And with genotype 2 doing so well with the new oral treatment, why do the triple therapy?
Helpful - 0
Have an Answer?

You are reading content posted in the Hepatitis C Community

Top Hepatitis Answerers
317787 tn?1473358451
DC
683231 tn?1467323017
Auburn, WA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Answer a few simple questions about your Hep C treatment journey.

Those who qualify may receive up to $100 for their time.
Explore More In Our Hep C Learning Center
image description
Learn about this treatable virus.
image description
Getting tested for this viral infection.
image description
3 key steps to getting on treatment.
image description
4 steps to getting on therapy.
image description
What you need to know about Hep C drugs.
image description
How the drugs might affect you.
image description
These tips may up your chances of a cure.
Popular Resources
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.