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Telaprevir results???


Seems a bit confusing.

How many telaprevir patients are actually cured after just 24 weeks of treatment? Vertex is being a bit cagey, saying only that 70% of the 75% of viral cures were in patients treated for 24 weeks.
Bank of America/Merrill Lynch analyst Rachel McMinn estimates that this translates in 55% of telaprevir patients overall achieving viral cure with a 24-week treatment regimen. That's lower than what was observed in the previous phase II studies of telaprevir. Vertex says more advanced, difficult-to-treat hepatitis C patients enrolled in the phase III study compared to previous studies explains the difference.

This metric is important because cutting treatment time for hepatitis C in half (from one year to six months) is one of the key selling points that Vertex will use to market telaprevir -- and potentially differentiate the drug from Merck's boceprevir which will likely require longer treatment.

That message is diluted a bit, however, if the study results show that only about half of hepatitis C patients treated with telaprevir will be cured at 24 weeks (the rest needing 48 weeks of treatment.) Half is still better than none, which is what happens today, but half isn't as good as it could be, either.
26 Responses
338734 tn?1377163768
It sounds like it takes so d*** long to get a drug to market, that they get leap-frogged by competition before they can recoup investment!

I see Telaprevir soon being sidelined by even newer drugs (NS5A, etc.). Tough business, even though so lucrative.

99% SVR with Bocep? That must be the SVR rate in the group that attained SVR (with some obscure kind of rounding error). ;-)
Avatar universal
Bocep studies have cure rate of 80 to 99%...in the trial 2 studies
Avatar universal
Boceprevir did not have 80 - 99% cure. That is absurd!  I remember it being the same or slightly better then telaprevir in study data I saw. Please post links that show those results. Please post correct info if you are going to post.
Avatar universal
Here is the correct Boceprevir data for anyone interested.


Those taking peginterferon alfa-2b (1.5 μg/kg once weekly) and ribavirin (800 – 1400 mg/daily, dosed by weight) followed by boceprevir (800 mg 3 times a day) achieved an SVR rate of 75%, almost double the nonboceprevir control group’s rate.

Avatar universal
75% .im only off by 5%
Avatar universal
you said 80-99%, not 80% . that means you were off 20%. don't try and spin this any different. it was wrong info!
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