I recently met with a hepatologist to discuss end of treatment details; I was previously scheduled to conclude treatment tomorrow, January 25. Based on new data, we determined it would be in my best interest to continue with my current regime for a total treatment period of two years.
Soooo… I’m currently in treatment week 71 of 104, with PEG-Intron 204 µg/week, and riba 2.0 g/day. Currently, I’m now scheduled to conclude treatment Sept 15, ’08.
A quick overview of my history and stats for anyone interested:
Dx 11/04 with HCV GT-1
Grade 3, Stage 3/4 per biopsy 1/05
Commence treatment 2/05 with Pegasys/Riba
Slow response at 12-week juncture; did not achieve 2-log drop
Increase riba dosage to 1800 mg/day, and extend Tx to 56 weeks.
Achieve UND (<50 IU/mL) by week 20
Experienced moderate sides with mild depression, severe fatigue, and significant diarrhea.
Relapsed at 30 days post Tx.
Commence re-treatment with PEG-Intron/riba 9/06.
Assigned dosages are as follows:
PEG-Intron 204 µg/week (~2.31µg/kg/week)
2.0 g ribavirin/day (~23.1 mg/kg/day)
Baseline HGB was 17.4; currently at 13.1 (no EPO required)
HCV serum RNA negative per bDNA (<615 IU/mL) assay week 4
HCV serum RNA negative per TMA (.74 = F-4, cirrhosis). While these specimen results may have been skewed due to gross hemolysis/haptoglobin results (the test sample was taken during treatment), my proven histology from biopsy in early ’05 indicated late stage 3, early stage 4 damage. Given that I have demonstrated progressive liver disease, it’s not out of line to assume I have indeed entered into cirrhosis since the last biopsy.
The rather disappointing results from the HALT-C study just released in the ’07 AASLD meeting in Boston played a roll as well; there are very few options outside of eventual transplant available for me in the event of potential relapse, *at this time*.
My liver is fully compensated, my lab values remain strong, and I tolerate treatment relatively well, from a subjective as well as hematological standpoint. I’m pre-approved for meds through Schering-Ploughs Commitment to Care patient assistance program; additionally, I was approved for SSI last year. I’m socially, financially and psychologically in decent shape; might as well take my lumps while my health holds up.
I thought I’d post this info to help others gain perspective into their own treatment protocol, maybe some of us can learn from this.
Here’s to wishing everyone well in there own travels;
Take good care, all—