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Avatar universal

Treatment duration

Hello,  I have been checking this sight for a few years and found it to be informative, valuable and reassuring.  I was first diagnosed with Hep C in 2001 after probably contracting virus in 1969.  Genotype 1.  As my health was generally good I have waiting for improvements in SOC treatment success.  Levels generally around 400,000,  ALT 55.  at I have taken the leap and am now 12 weeks into SOC & Filibuvir/placebo clinical trial. I had >2.09 log reduction at week 4 and < 15 at week 8. Undetectable.   No RVR but EVR which is quite the difference in treatment duration. I feel I will never make another 36 weeks of this hell.  Depression is terrible,  started Wellbutrin last week, not sure if it has helped yet. Have had quite the rash but find psycological sides harder than physical

As I could have been only a week or 2 from RVR arm of study (tx 24 weeks)  I am questioning adding a extra 24 weeks SOC treatment. No testing between week 4 and 8.  I am going to have a hard time going another 12 weeks as it is.

My viral load at test screening was 896000,  highest ever by far,  which I thought was odd

I am open and welcome any comments, suggestions or what have you.

Thanks

9 Responses
717272 tn?1277594380
Ouch.  The only way to get an American doctor to sign on for 24 wk. geno 1 TX is to be undetectable at the 4 week PCR (RVR).  Since you are in a study, you are guided by their protocol.   Talk to them and see if there is any wiggle room, but I doubt if there will be.  They must follow their protocol.  

If the Wellbutrin has not modified your mood by 2 weeks, you may want to switch to a different AD.  I went through 4 or 5 before I found one that was appropriate for me (I could not sleep on Wellbutrin or Zoloft).  Anti-depressants are not a one-size-fits all drug.  Stick with it until you get the right one for your own brain chemistry.  They really do work and can make a huge difference in handling chemo.
Avatar universal
Hi Scuddy,

I'm not familiar with your trial so I don't know what kind of side effects are associated with your trial drugs.  I know interferon and ribavirin can cause psychological problems and hopefully the AD will provide some relief soon.  

Having failed 72 wks of SOC and speaking for myself I would have been delighted had I been UND by 8 weeks and given the fact you are responding so favorably I would go the distance even if I had to crawl to the finish line because you don't want to have to this again.  
I have no other choice but to give it another go when PI's hit the market but you do have the opportunity to make this a one time deal.  Use all the helper drugs available, counselling, leave of absence, whatever it takes to get you through to the end because we aren't getting any younger and the older you get the harder it gets.  Take advantage of that trial and that EVR.

Hope you feel better soon,
Trinity

Avatar universal
Ouch Exactly! I am in Canada and the protocol is the same up here.  The question for me is do I really need 24 more weeks of "treatment" because of missing rigid RVR by a few weeks. It's a tough decision to make, I will attempt to get through next 12 weeks and decide then.

In regards to the Wellbrutin, it just occured to me that it must be doing something or I would not be engaged in this conversation.

Thanks for your comments

  
Avatar universal

Phase 1 study of Filibuvir showed no major increase of sides. I am in Phase 2 trial. Here is a link to Phase 1 study results. This is a very promising PI and might interest you down the road.
www.natap.org/2009/EASL/EASL_34.htm

It would appear that I am in placebo group so I am definitely delighted with UND,  and loved hearing your words of encouragement.

Thanks
Avatar universal
Scuddy,

Thanks for the link, I'll check it out.  

In my humble opinion (we all have one which you will find out if you stick around) your viral load wasn't low going in and without that RVR and given you're pretty sure you're in the placebo group you need the full 48 weeks for the best chance at SVR.  The decision is yours and only you know what you can endure but the stats are out there and anything less than 48 wks is not advised under the circumstances you present.

Keep posting and reach out to others who can relate.  We'll hold your hand or drag you by the ear, whatever it takes.  The first 12 wks are tough on everyone.  Hang in there, things will level out.

Trinity
717272 tn?1277594380
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