To start it off, I will say that I was UND at 9 weeks post treatment.
I forgot to mention above I also want to know the number of weeks of treatment....
Liver Biopsy: Grade 2 Stage 2 (Sept. 2, 2011)
Pretreatment VL: 14,000,000 (July 7, 2011)
Tx Drugs: Interferon, Riba, Incivek (48 weeks)
Tx Start Date: Sept. 26, 2011
Tx Stop Date: Aug. 25, 2012
All of my Viral Loads except the last one were done using the test that quantifies down to 43.
Week 4: HCV RNA <43 Detectable
Weeks 8, 12, 16, 20, 24, 28, 32, 36: (All) HCV RNA <43 Undetectable
Week 48 (EOT): Undetectable with the Hepatitis C Viral RNA, Quantitative TMA (lower limit of detection is <5)
My 12 week VL wil be Nov. 19th
Worst Side Effects: Bad Rash, Nausea, Anal/Rectal Problems (crapping shards of glass)
Lowest Hgb. 10.2. No dose reductions. No rescue meds. No transfusions.
Although I was told at Tx start that I would be given rescue drugs for low Hgb if needed, when my Hgb actually did drop and I asked them to get organized in case I needed Procrit, they said they do not give Procrit. They said they would dose reduce by half (1200 mg to 600 mg.) instead of giving Procrit. (I fired that doctor.)
I went straight home and within an hour I booked an appointment with a new Hepatologist in a larger city. That Hepatologist gives Procrit.
There is no way I would ever reduce my Riba in half, maybe 200 mg less, but never in half.
Pegasys, Riba 1200mg, Victrelis (48 weeks)
Start date: Oct 30, 2011
Finish date: Sep 29, 2012
Pre-tx viral load: 824,711
IL28B subtype not done
Previous tx: 2006 for 48 weeks, non-responder
Liver condition: Cirrhosis. Dx'd on hospital admission for variceal hemorrhage in 2005. No Bx done.
Viral testing done with Roche <43 sensitivity.
Week 4: Detected, 0.8 log drop
Week 8: Detected with Quant <100
Week 12: Detected (Qual) and Undetected (Quant)
Week 24: Undetected
Week 48: Undetected one week post EOT
Will get post 3 month PCR around January and 6 month in April.
I had no dose reduction this round of treatment. I had persistant neutropenia and anemia for most of treatment. To avoid reduction I began Neupogen at week 12 and Procrit at week 16. By week 21 we'd bumped the Procrit to 60,000u weekly and Neupogen to x3 weekly. With this combination my Hgb stayed in the mid 9's-low 10's and ANC stayed between 0.3-0.7.
Had significantly more nausea and poor appetite than with previous treatment.
This may be of interest to others starting Victrelis. On my previous tx with SOC the Hgb remained in the low 11's without rescue meds but I was only taking 1000mg of Ribavirin. This round we'd bumped the Riba to 1200 and of course added the Victrelis. Beginning weight both times about 160 lbs. Thanks for all the effort you've been putting into these stats, marty.
I don't know if your spread sheet expands to show more than what printed, but in my husband's case, tx was discontinued on April 12, 2012, week 28 of triple tx w Inc., due to viral breakthrough. Everything else in your chart for my husband is accurate.
Confirmed w/ VL of 8.47 M, June 2011
Tx. Inf.,ribavirin 1000 and victrellis
Fibrosure showed F0
Tx. Start date: April 8, 2012
Tx. Stop date: Oct. 20, 2012
Viral load at week 4= 9020
Week 8: UND
Week 24: UND
Had no dose reductions.
Added procrit when hgb was at 9.6
Post tx. VL will be in January 2013 (12 week post)
Oh yah, that's 28 weeks, total.