Avatar universal

Urinary Tract infection on treatment

Has anyone had a urinary tract infection Or cystitis during treatment. I had one four weeks ago that responded to antibiotics from the trial nurse. I am 20 weeks into the Gilead 5881 and 9541 trial with SOC.

But three weeks later it came back and did not respond to the same antibiotics.  Now I have to wait for the antibiotics to leave my system and get a culture done. Another four to five days of discomfort.

I read online that certain treatments can create the same systems when leaving your system. Not sure how they would treat.

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1815939 tn?1377991799
I have not had a urinary tract infection on treatment.

You must have developed resistance to the antibiotic. I am a bit surprised that the trial nurse did not do a urine culture and sensitivity to begin with, before starting treatment. I am exceptionally surprised that she did not do a urine culture and sensitivity before starting you on antibiotics the second time, especially since it was only 4 weeks later.

They can run a culture and they can determine which anitbiotics the infection is sensitive to and which antibiotics the infection is resistant to. I woud think they would have done that, especially the second time around. If they had done that, they could have started antibiotic  treatment right away, but then when they got the culture results, including the antibiotic sensitivities, they could have immediately switched you to a different antibiotic because the test would tell them you were resistant to the antibiotic you were on.

Be sure this time when they do the culture they also run it for antibiotic sensitivities so they know which antibiotics it is sensitive to.

Here is a link explaining the lab testing:


"Tests: Common Laboratory Tests
Most UTIs are detected by performing a urinalysis and then confirmed with a urine culture. If there are pathogenic bacteria present, then susceptibility testing is done to make sure that the antibiotic that the doctor chooses will effectively treat the microorganism causing the infection.

Urine Culture. Urine is streaked on a thin layer of nutrient gel (agar plate), then incubated for 24-48 hours. Any bacteria that grow on the agar are counted and identified. Usually, if a person has a UTI, there will be a high colony count of one type of bacterium that will be present. ...  If there is a predominant growth of one type of bacterium present in high number, then susceptibility testing is done (sometimes the doctor may refer to it as “sensitivity” testing). The ability of different antibiotics to inhibit the growth of the bacteria in a test tube or in an agar plate predicts which antibiotics will work best in the affected person."

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87972 tn?1322661239
To tag onto Pooh’s thoughts make certain your neutrophil values are adequate; if not, the antibiotics won’t have much to work with.

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Avatar universal
Many thanks for your information. Very helpful.  It was my fault they did not run a culture the second time as I had enough antibiotics for another treatment and it had worked so well the first time. The nurse was upset I did not call as she said I should not have got it back so quickly and she would have had me do a culture test.   Live and learn. I have them when younger and one dose of antibiotics has always worked.  The treatment must be affecting the response.

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