Vitamin D and treatment

[momof2jewels]

I've come across many books and articles which claim that taking Vitamin D during treatment increases your chances of clearing the virus.  Anyone had experience with this?

[willbb]

Data on Vit D as it pertains to  fibrotic  progression  is somewhat conflicting :

http://www.ncbi.nlm.nih.gov/pubmed/22151003


Lower plasma 25-OH vitamin D levels were significantly associated with fibrosis progression >0.101 U/year in F0-2 patients (P = 0.013). Combined analysis of both variables revealed a highly significant additive effect on fibrosis progression with 45.5% rapid fibrosers for bAt[CCA]-haplotype and 25-OH vitamin D < 20 μg/L compared with only 9.1% for the most favourable combination (P = 0.006). In multivariate analysis, the bAt-haplotype was an independent risk factor for fibrosis progression (P = 0.001; OR = 2.83).

CONCLUSION:

Low 25-OH vitamin D plasma levels and the unfavourable VDR bAt[CCA]-haplotype are associated with rapid fibrosis progression in chronic HCV patients. In combination, both variables exert significant additive effects on fibrosis progression.

© 2011 John Wiley & Sons A/S.

[Bali05]

25-OH-vitamin D level is not associated with the outcome of antiviral therapy in naïve genotype 1 HCV infected patients

Background and aim:
Because of conflicting results, the role of vitamin D as a potential predictor of sustained viral response (SVR) to antiviral therapy in patients with chronic hepatitis C remains to be defined. The aim of the study was to assess the correlation between vitD concentration and the viral response.

Methods:
The study population consisted in treatment-naïve genotype 1 patients enrolled in a randomized controlled prospective study (Gastroenterology 2006;131:1040-8). 516 patients received peginterferon a-2a (P) 180 µg/week plus ribavirin (R) 800 mg/day for 24 weeks; 349 patients with undetectable HCV RNA (< 50 IU/mL) at week 24 were randomized to continue PR (173) or continue P alone (176) until W48. 25-OH-Vitamin D concentration (Diasorin) was measured at baseline on left-over serum and the correlation between the vit-D concentration and viral response at W24 and SVR was assessed.

Results:
489 patients could be analysed for the correlation study with viral response at W24 and 313 (147 non responders at W24 + 166 responders who continued PR until W48) for the correlation study with SVR. Their characteristics were: male: 59%, BMI: 24.6 kg/m2, viral load: 6.2 log10, Metavir fibrosis score (centralised lecture): F1 30% F2 34% F3 27% F4 9%. The median vitD concentration was low (13.4 ng/mL) in the overall population. The median vitD concentrations were similar in the viral responders at W24 (13.5 ng/mL) and in non responders at W24 (13 ng/mL) but also in patients with SVR (12.8 ng/mL) and with no SVR (13.35 ng/mL). The median vitD concentrations according to fibrosis score were as follow: F1: 14.30 ng/mL, F2: 13.50 ng/mL, F3: 13.30 ng/mL, F4: 12.80 ng/mL (NS).

Conclusion:
In our study, 25-OH-D3 levels before antiviral treatment were not associated with the outcome of antiviral therapy in naïve genotype 1 HCV infected patients. Moreover no significant association could be found with the fibrosis score.


http://mobile.ilcapp.eu/EASL_161/poster_24462/program.aspx

[Proactive]

CONCLUSIONS:
Chronic hepatitis C virus infection is associated with vitamin D deficiency. Reduced 25-hydroxyvitamin D levels and CYP27B1-1260 promoter polymorphism leading to reduced 1,25-dihydroxyvitamin D levels are associated with failure to achieve SVR in HCV genotype 1, 2, and 3 infected patients.

http://www.ncbi.nlm.nih.gov/pubmed/21145801

[Proactive]

http://www.google.com/webhp?sourceid=chrome-instant&ix=sea&ie=UTF-8#hl=en&output=search&sclient=psy-ab&q=hepatitis%20c%20vitamin%20d%20deficiency&oq=&aq=&aqi=&aql=&gs_nf=&gs_l=&pbx=1&fp=98d5445c5607bd30&ix=sea&bav=on.2,or.r_gc.r_pw.r_qf.,cf.osb

[ceanothus]

I don't have the specific info you are requesting, but wanted to say that imy primary physician (who is incredibly dedicated and brilliant) has had most of her patients taking 2,000 I.U. of vitamin D daily as a basic preventive health measure. She said studies show a vitamin D deficiency is very common in our modern society, and that there are a broad range of health benefits conferred by an adequate level of vitamin D. It is a very cheap supplement if purchased at Costco or Trader Joe's, so it seems like a no-brainer to me. I do still hope someone more knowledgeable will post about how it relates to Hep C and tx.

[nygirl7]

Phones........even my netbook or Ipad typing makes it look like I'm insane.  Oh wait........ ;)

MikeSimon has posted some really terrific articles on this very subject. They should come up easily enough!

[ninjamonkey]

I meant search old threads they may help you out. Sorry my phone is being weird don't know why that took so many post

[ninjamonkey]

I meant s

[ninjamonkey]

There is already a very similar thread to this one

[jules2551]

Get your Vit D levels checked and talk to your Dr about it.  Mine was on the low side so Dr told me to take it.

Have a great day!
Jules