What are chances of viral breakthrough during last half of 48 week tx.?

[tonybuck]

Morning Team,
Reaching the end of tx. and I am trying to put things in perspective any insight would be appreciated. I was going thru my labs and noticed my enzymes climbed after week 24 from slightly elevated to alt 81 and ast 61 and have stayed that way thru week 36 labs. Also the sensetivity of the test they are doing I don't undertsand but I believe they are testing to
<100 copies/ml      <29 iu/ml
Infected:1985 21 years ago

[tonybuck]

First biopsy: 2000 (waiting to obtain results of diagnosis) mild damage at this point. Gastro recommendation to Wait and see and redo biopsy in 6 years.
Second biopsy :2006
   Liver needle biopsy: chronic hepatitis.
   Etiology: hepatitis c.
   Degree of activity:grade 2 (mild portal inflammation with piecemeal necrosis and spotty necrosis).
   Degree of fibrosis/cirrhosis:grade 2 (periportal fibrosis with rare septa,no bridging).
   Modified hai (knodell) score : 6
   Periportal piecemeal necrosis: 1.
   Intralobular degeneration/ focal necrosis: 1
   Portal inflammation: 3.
   Fibrosis: 1.
   Steatosis: mild (1+) steatosis is present.
   Other lesions: negative pas and iron stain.
   Co-existing pre-neoplastic lesions: none.
Grading and staging schemes are from Ludwig and Batts

Gastro explained that since first biopsy. Grade and inflammation both increased from a 1 and 2 to a 2 and 3.

Enrolled in Schering-Plough sponsored study comparing genotype 1 not previously treated. 2880 subjects at 100 various sites. Subjects will be selected to take the following dosing.
  Peg-Intron 1.5ug plus Rebatol
  Peg-Intron 1.0ug. plus Rebatol
  Pegasys 180ug. Plus Copegus.

[tonybuck]

Boy I got this post all messed up It been just one of those brian fog things.

[genedog]

for me i was clear till week 40 then  had viral breakthrough.alt was going up from week 30 did 55 weeks

[genedog]

if you know snook his alt was high all time time on tx and he is clear