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158241 tn?1237723123

amantadine & quality of life

In Germany amantadine is on the market against influenca and Parkinson's disease.

Eur J Gastroenterol Hepatol. 2007 Aug;19(8):639-646.
Efficacy of amantadine on quality of life in patients with chronic hepatitis C treated with interferon-alpha and ribavirin: results from a randomized, placebo-controlled, double-blind trial.
Kronenberger B et al.
AIM: The aim of this study was to investigate whether amantadine reduces deterioration of quality of life in patients with chronic hepatitis C during and after treatment with interferon-alpha (IFN-alpha) and ribavirin.
PATIENTS AND METHODS: In this randomized, prospective, placebo-controlled, multicenter trial, previously untreated patients with chronic hepatitis C were treated with IFN-alpha plus ribavirin and randomized for treatment with amantadine (200 mg/day, orally, n=136) or placebo (n=131). Quality of life was assessed with the 'Profile of Mood States' scale and the 'Everyday Life' questionnaire at baseline, treatment week (TW) 8, TW24, TW48, and at follow-up.
RESULTS: Early during treatment at TW8, quality of life was not different between patients in the control and the amantadine group. At TW24, the control group but not the amantadine group, however, showed significant deterioration of the modalities depression, fatigue, and vigor compared with baseline. Especially, nonresponders in the amantadine group showed significantly lower deterioration of depression, anger, mind function, everyday life, and zest for life than those in the placebo group. After treatment, the beneficial effects of amantadine disappeared. CONCLUSION: The addition of amantadine to IFN-alpha plus ribavirin combination therapy may reduce deterioration of depression, fatigue, and vigor during treatment but does not affect quality of life after treatment.
PMID: 17625432

11 Responses
Avatar universal
Always wondered why Ribavirin was never sold as a cure for the flu, nice to know amantadine is.
Whatever happened to conjugated Ribavirin, less anemia.
btw do you have any info on misletoe

CS
29837 tn?1414538248
Not to discourage anyone, but I was on Ribavirin, Pegasys and Amantadine treatment (my 3rd). The conclusion of the Gastro was that it didn't make any difference...

Magnum
148588 tn?1465782409
Amantadine is no longer considered to even be very effective for flu in this country and was long ago discarded as adjunct to HCV therapy. Ribavirin is sold as an inhaler in Mexico to treat influenza and also has some pediatric uses in this country in aerosol form.
158241 tn?1237723123
>"Amantadine is no longer considered to even be very effective for flu in this country and was long ago discarded as adjunct to HCV therapy."

Could you please tell any citation for this statement? If you read the study carefully, you will notice, that A. is not suggested to increase SVR, but has shown beneficial efects of sides of therapy. This is a small, but important difference.
A meta analysis of 31 studies shows a better SVR rate in difficult to treat patients: http://tinyurl.com/33bd3j
Same results here: http://tinyurl.com/2pq2o5
More Clinical trials to compare SVR rates are still ongoing:
http://www.clinicaltrials.gov/ct/gui/show/NCT00299923?order=3

Be carefully with opinions, which are not a result of published facts.
148588 tn?1465782409
http://www.msnbc.msn.com/id/10851668

1/14/06
"The government for the first time is urging doctors not to prescribe two antiviral drugs (rimantadine & amantadine) commonly used to fight influenza because of concerns about drug resistance..."

My point was that anti-inflamatories, marijuana, painkillers, etc. etc. can reduce side effects, enhance patient compliance, and ultimately result in a larger % of SVR - all without creating the resistant strains of virus that may result from using specific anti-viral drugs. We've created enough problems in the bacterial world by over-using antibiotics - we don't need to do the same thing with viruses.
148588 tn?1465782409
From the above referenced article:

Percentage of amantadine/rimantadine resistant  H3N2 influenza A virus:
'04 flu season -  2%
'05 flu season - 11%
'06 flu season - 91%

Probable cause of H3N2 resistance :  "...overuse of the drugs abroad, such as in countries that permit the drugs to purchased without a prescription."
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