This info is not put together, just cut and pasted. Hope you can work your way thru it. later, jerry---------Colon complete complex contains: Fiber complex (2000 mg) x2 Lactobacillus F19 probiotic (14 mg) x 2 Lactospore prebiotic (20 mg) x2 I use Smartbomb.com as a source except for the Resveratrol. I will go with Lactulose amd Lactobacillus GG when I use up what I have. ------------------------------------------------------------------------------------ What to take while on tox per HR The supplements while on tx question is difficult, because the ones having antifibrotic promise are almost all antiinflammatory, somewhat reducing the initiating events at the dendritic cell/lymphocyte interface.I know this sounds technical. Most of them also have, paradoxically an improving effect on some aspects of lymphocyte function, as the spectracell test clearly shows. Bottom line, NO CLEAR ANSWER possible regarding use during tx. But a moderate use of NAC/VitC, TMG, ALA ( those are quite cheap and possibly PPC (since it was actually shown to help the SVR rate) is probably a good idea even during tx. Vit D3 is good, but it would be best to know ones serum level. Also some Inulin is inexpensive (trader joes) and a very good well researched prebiotic. To get any lactulose here in the US is not trivial.
Hepatogastroenterology. 1998 May-Jun;45(21):797-804.
Polyunsaturated phosphatidyl-choline and interferon alpha for treatment of
chronic hepatitis B and C: a multi-center, randomized, double-blind,
placebo-controlled trial. Leich Study Group.
Niederau C, Strohmeyer G, Heintges T, Peter K, Göpfert E.
Department of Medicine, Heinrich-Heine-University of Düsseldorf, Germany.
[email protected]
BACKGROUND/AIMS: Polyunsaturated phospatidyl-choline (PPC) has been shown to
reduce serum aminotransferases in experimental hepatitis. This multi-center,
randomized, double-blind, placebo-controlled trial evaluated the effects of PPC
in patients with chronic hepatitis B and C in combination with interferon alpha
2a or 2b. The diagnosis of chronic viral hepatitis was based on an abnormal serum
alanine aminotransferase (ALT) value (more than twice the upper value of normal),
viral replication and chronic hepatitis found on liver biopsy. METHODOLOGY:
Patients received 5 million I.U. (Hepatitis B) and 3 million I.U. (hepatitis C)
interferon s.c. thrice weekly for 24 weeks, respectively, and were randomly
assigned to additional oral medication with either 6 capsules of PPC (total daily
dose: 1.8 g) or 6 capsules of placebo per day for 24 weeks. Biochemical response
to therapy was defined as a reduction of ALT by more than 50% of pre-treatment
values. The responders were treated for further 24 weeks after cessation of
interferon therapy with either PPC or placebo. RESULTS: 176 patients completed
the study protocol (per-protocol population: 92 in the PPC and 84 in the placebo
group). A biochemical response (> 50% ALT reduction) was seen in 71% of patients
who were treated with PPC, but only in 56% of patients who received placebo (p <
0.05). PPC increased the response rate in particular in patients with hepatitis
C: 71% of those patients responded in the PPC group versus 51% in the placebo
group (p < 0.05). PROLONGED PPC THERAPY GIVEN TO RESPONDERS BEYOND THE CESSATION
OF INTERFERON THERAPY TENDED TO INCREASE THE RATE OF SUSTAINED RESPONDERS AT WEEK
48 IN PATIENTS WITH HEPATITIS C (41% VERSUS 15% IN THE CONTROL GROUP; p = 0.064).
In contrast, PPC did not alter the biochemical response to interferon in patients
with hepatitis B. PPC did not accelerate elimination of HBV-DNA, HBeAg and
HCV-RNA. CONCLUSIONS: In conclusion, PPC may be recommended in patients with
chronic hepatitis C in combination with interferon and after termination of
interferon in order to reduce the high relapse rate. PPC may not be recommended
for patients with chronic hepatitis B. In contrast to IFN and other antiviral
agents PPC does not carry major risks and is tolerated very well.
Inulin and lactulose will beneficially grow/foster slightly different strains of beneficial/nontoxic/noninflammatory/intestinal epithelia feeding(yes!) bactreria that will together more efficiently push back the dangerous ammonia/slew of other toxins producing/proinflammatory harmful bacteria to small numbers by competing for available space and by the production of natural local antibiotic factors that reduce the growth potential of the more pathogenic species.
The importance of blocking/reducing proinflammatory signals and toxins to the liver in a condition of compromised liver function and an already inflammatory state in the liver cannot be overstated.
Similarily the related concept of reduction of "leaky gut syndrome"/ amount of residual epithelial leakage due to compromised intestinal endothelial function to a minimum by "eubiosis" is of paramount importance.
A teaspoon of Glutamine/day is also further important in that context, since the rapidly dividing intestinal epithelial cells require this particular amino acid in particular high amounts.