can pegasys elevate liver enzymes

[maboutabl]

i am in week 11 of treatment, my ALT was 180 at the beginning, after 4 weeks became 105, after 6 weeks 75
then after 8 weeks 220 after 10 weeks 904....?
so what is happen? what is wrong?
my PCR was 80000 then become undetectable afer 4 weeks
i do ANA before the beginning and was negative
what should i do?
continue the treatment or not

[maboutabl]

thank you apache
yes i done recent PCR after the last pegasys (no 11 shot) it is negative
now i done ANA, SMA,LKMA, AnDNA and the result well be tomorrow
i hobe that it well be negative
my billirubin is 1.25 this mean that it is borderline
i have two opinoin from my doctors
one said that i must stop tt for two weeks and see what well happen to liver enzymes
the other said that continue tt till the result on investigation of autoimmune hepatitis appear
actually i prefer the first opinion and i dont take the tt
and i am waitting for the result of my blood work

[JackABCD]

You should see your hepa, It is not common.

[apache1]

Well.... I am no Dr and No Doctors here.
In my laymen opinion, could be autoimmune Hepatitis. But this is just a guess, at best. I could be all wrong.
Its confusing for autoimmune that your ANA was normal before TX. Maybe you developed it during TX ? Did your BX show any autoimmune hep ?
You need your Dr to figure this out. Or get a second opinion from another Dr.

What genotype are you. And how long is your tx suppose to be.
If you are a geno 2 or 3 then 12 wks tx might be enough since you had a RVR.
Have you done your 12th shot of ifn ?
Be very careful here, 904 ALT is very high. Do you have jaundice now ? Don't think you want to chance going into the thousands.

Have you got your ANA and smooth muscle antibody checked again ?
What has your Dr recommended ?
IMO, You need to be watched very carefully now by a Hepatologist or at the very least a good gastro.

apache