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Avatar universal

do you think this is a relapse

im new to this, so here goes- told i have hep c nov 09,  geno 2 b, started tx april 2010 but only lasted 16 weeks {instead of 24]due to low platlets, low white and low red count, ended up in hospital for 4 days, tested neg at 4, 12 and 16 weeks on tx,  then tested neg at 12 week post tx. just after that had case of flu with slight fever, headache  for 2 days, muscle aches, pain in elbow joints and sleeping in daytime etc...not been called up for my 24 post tx pcr yet even tho its been 30 weeks post tx, any replys will be very welcome as i'm very worried  thanks
14 Responses
Avatar universal

Ditto to what James10500 said, but the following study may be somewhat reassuring for now.

Sustained virological response (SVR) to hepatitis C treatment is usually defined as continued undetectable HCV viral load 24 weeks after completion of therapy. Michelle Martinot-Peignoux and colleagues from France evaluated whether assessment of serum HCV RNA 12 weeks after the end of treatment was as relevant as 24 weeks for determining SVR.

The investigators analyzed sustained treatment outcomes among 573 chronic hepatitis C patients who received pegylated interferon (Pegasys or PegIntron) plus ribavirin and had an end-of-treatment virological response. Viral load was measured using a sensitive TMA assay with a lower limit of 5-10 IU/mL. Viral relapse was defined as reappearance of detectable HCV-RNA between the end of treatment and post-treatment week 24.


All 573 participants had undetectable HCV RNA at the end of treatment.
At 12 weeks post-treatment, 409 participants still had undetectable viral load.  
At 24 weeks post-treatment, 408 participants (71%) achieved SVR.  
Looking back at week 12 results, all but 1 of the patients who were undetectable at week 12 remained so at week 24.
Week 12 response had a positive predictive value of 99.7% for predicting Week 24 SVR.  

The researchers concluded that assessment of serum HCV RNA 12 weeks after the end of treatment using a highly sensitive TMA assay "is as relevant as after 24 weeks to predict SVR and make decisions on the management of treated patients, suggesting a new definition for SVR."

Institut National de la Santé et de la Recherche Médicale, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, Université Paris VII, Paris, France; Service d'Hépatologie, Hopital Beaujon, Clichy, France.


M Martinot-Peignoux, C Stern, S Maylin, and others. Twelve weeks posttreatment follow-up is as relevant as 24 weeks to determine the sustained virologic response in patients with hepatitis C virus receiving pegylated interferon and ribavirin. Hepatology 51(4):1122-1126 (Abstract). April 2010.

Avatar universal
I doubt very much that it is a relapse. First of all you are a 2b, which is the easiest to treat successfully. Secondly, the vast majority of relapses take place in the first 30 days off treatment. I don't think you have anything to worry about.
Avatar universal
thanks susie, always worries me because i only done the 16 weeks
Avatar universal
also i could'nt eat any food for days and lost a lot of weight
Avatar universal

You would think that you have not relapsed,seeing as you were UND at wk.4 and 12 of tx. Also being UND at wk. 12 post treatment is a good sign. However just to be sure you should consider doing your 6 mo. post test to expel any fears you still have.

Hope that helps some

Avatar universal
forgot to add that i had night sweats.   as you all can see i still suffer with brain fog,ha
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