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Avatar universal

has anyone completed tx with riba, without inf?

I see alot of comments about riba rash, riba rage, etc. and wonder how much has to do with the inf/riba combo.  It seems riba in another combination might be less toxic. Does anyone know?

Prior to these new trials I'm not seeing any info on riba without intf.  The trial I'am in for almost 2 weeks is riba w 7977, this of course is so new there's no info out there.  
11 Responses
87972 tn?1322664839
I think both ‘riba rash’ and ‘riba rage’ are probably attributable to interferon rather than the drug ribavirin;  It’s difficult for patients to discern what adverse side effects belong to which drug; the two have been used side by side now for years. Speak with your doctor about your concerns; these discussion groups are better suited to generating questions than providing answers.

Good luck with your clinical trial-

--Bill
Avatar universal
Back in the day, I was on interferon alone for 6 months with absolutely no side effects. We threw the riba in and I got pounded by all of them. Each pt is different and there is no telling whether it was the riba or the synergistic effects of both drugs, which is what I am inclined to believe. ..Mark
163305 tn?1333672171
Maybe has a good point.
However, I noticed the morning after my interferon shot  the so called riba rage, ready to obsess over any and all !
I think riba just increases the tension, that's my take.
Riba rage sounds much cuter than interferon rage, doesn't it?

Apologies to anyone who may have gotten my unintended rath :)
Avatar universal
It is definitely  easier to say...Mark
Avatar universal
I am on Riba/no interferon. It has been 10 days. I don't have a rash or rage, though I find myself feeling impatient at times and definitely tired, but that could be fatigue from hep.c/liver dysfunction.
Avatar universal
The Riba never seems to bother me. I do get tired, the day after my Interferon shot though. When they introduced the protease inhibitor (Victrelis) I became anemic, and started getting infections...tooth abcess, little cracks nearmy nails, that wont heal, etc.
   I have noticed I cry alot more....and if I do get mad, it feels more impulsive. So I make sure to avoid conflicts~ good luck to you
1644356 tn?1349786811
I am on trial for 12 weeks Riba and 7977. So far very few sides except headache the first few days. Week one results were UNDETECTED!!!
Also liver functions returned to normal. Good luck in your trial. I am so grateful to be a part of this trial.

Jill
Avatar universal
Thanks for the feedback.

At the start VL was 4mil, day 7, 89.  I'm on my way, ya-hoo!

Today is the beginning of my third week.  Very few sides.  Mild fatigue at times but still go to the gym and swim the same as usual.  Headachy, heartburn and sometimes just don't feel 100%, but nothing dramatic.  I'm hopeful and grateful to be in this trial - riba & 7977.
Avatar universal
Don't know how I missed this before but that's great that you made UND the first week.  That must give you encouragement.  Your right the sides aren't so bad although this headachy feeling, which is not even full blown can be annoying, it's nothing compared to some sides.
Best of luck...
962117 tn?1416362216
Great news about your vl Mari!!  Will pray for your UND!!
384013 tn?1333026171
Praise the Lord on the numbers!  Those are fabulous!  Very excited for you.  Will be praying for UND and SVR for all of us!
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