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helicobacter pylori and hep c treatments
Today is my last day of treatment for Helicobacter pylori. I will be starting treatment for hep c Wednesday. Will this make me more nauasa?
Thanks for the info I'm beening treated for both by the same Dr. So hopefully he will take that all in concerderation.
Ask your doctor to test you to make sure the H.Pylori is gone. Having H.Pylori lowers Hep C treatment success.
Co
Effect Of Helicobacter Pylori Infection on Hepatitis C Virus Infection.
H.T. El-Zimaity, B. Yoffe, T. Tabassi, B. Hollinger, S.A. Abudayyeh, Z.Z. Nurgalieva, F. Hammoud, B.S. Anand.
Background
Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma (HCC). It has been observed that African Americans (AA) have a higher infection rate, an inferior response to anti-viral treatment, and are more likely to develop HCC compared to Whites. It is unclear why these ethnic differences occur. A possible explanation is the confounding effect of concurrent infections such as H. pylori (HP) is more prevalent in AA. HP might influences HCV infection by altering the host immune response. Aim: To compare HCV viral load and treatment response in HP positive vs. HP negative patients.
Methods
HCV was confirmed by positive HCV-RNA by PCR. HCV viral load was determined at baseline (prior to treatment), after 24 and 48 weeks of treatment, and at 6 month after stopping anti-viral therapy. Sustained virology response (SVR) was defined as negative HCV-PCR 6 months post therapy. Patients were treated with interferon alone or interferon and ribavirin combination therapy. HP status was assessed by serology (HM-CAP; Enteric Products Inc, Stony Brook, NY).
Results
107 patients with HCV infection were included (42 received monotherapy and 65 combination therapy). 42 (39%) were HP antibody positive. The SVR rate was lower among HP positive patients compared to HP negative patients (19% vs. 43%) (p = 0.01). By ordered logistic regression analysis, other factors associated with a lower SVR rate were genotype 1 and being African American. The baseline viral load was also lower in HP negative patients compared to HP positive patients (p<0.001). After treatment, the mean viral load in the non-responder patients (27 HP negative and 32 HP positive) was higher in HP positive patients (2.32 x 106 + 3.2 vs. 1.51 x 106 + 4.8 copies) (p = 0.056).
Conclusion
HP (H.Pylori) infection is associated with significantly lower sustained virologic response rate and a higher HCV viral load compared to patients without HP infection. The lower SVR rate in AA may be explained by the higher prevalence of H. pylori infection. Eradication of H. pylori infection might result in a significant improvement in the outcome of HCV treatment.
http://www.hcvadvocate.org/news/reports/DDW_2005/May%2017%20HCV.htm#May17_2
Co
Effect Of Helicobacter Pylori Infection on Hepatitis C Virus Infection.
H.T. El-Zimaity, B. Yoffe, T. Tabassi, B. Hollinger, S.A. Abudayyeh, Z.Z. Nurgalieva, F. Hammoud, B.S. Anand.
Background
Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma (HCC). It has been observed that African Americans (AA) have a higher infection rate, an inferior response to anti-viral treatment, and are more likely to develop HCC compared to Whites. It is unclear why these ethnic differences occur. A possible explanation is the confounding effect of concurrent infections such as H. pylori (HP) is more prevalent in AA. HP might influences HCV infection by altering the host immune response. Aim: To compare HCV viral load and treatment response in HP positive vs. HP negative patients.
Methods
HCV was confirmed by positive HCV-RNA by PCR. HCV viral load was determined at baseline (prior to treatment), after 24 and 48 weeks of treatment, and at 6 month after stopping anti-viral therapy. Sustained virology response (SVR) was defined as negative HCV-PCR 6 months post therapy. Patients were treated with interferon alone or interferon and ribavirin combination therapy. HP status was assessed by serology (HM-CAP; Enteric Products Inc, Stony Brook, NY).
Results
107 patients with HCV infection were included (42 received monotherapy and 65 combination therapy). 42 (39%) were HP antibody positive. The SVR rate was lower among HP positive patients compared to HP negative patients (19% vs. 43%) (p = 0.01). By ordered logistic regression analysis, other factors associated with a lower SVR rate were genotype 1 and being African American. The baseline viral load was also lower in HP negative patients compared to HP positive patients (p<0.001). After treatment, the mean viral load in the non-responder patients (27 HP negative and 32 HP positive) was higher in HP positive patients (2.32 x 106 + 3.2 vs. 1.51 x 106 + 4.8 copies) (p = 0.056).
Conclusion
HP (H.Pylori) infection is associated with significantly lower sustained virologic response rate and a higher HCV viral load compared to patients without HP infection. The lower SVR rate in AA may be explained by the higher prevalence of H. pylori infection. Eradication of H. pylori infection might result in a significant improvement in the outcome of HCV treatment.
http://www.hcvadvocate.org/news/reports/DDW_2005/May%2017%20HCV.htm#May17_2
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