Aa
Aa
A
A
A
Close
Avatar universal

hep-c

i am currently taking suboxeon for my back pain  , in about a month im going to start the pegasys hep c treatment . my question is can i take these together .
6 Responses
Sort by: Helpful Oldest Newest
766573 tn?1365166466
I have seen this question asked before.I can cut and paste a few studies but truly you ought to collaborate with the doctor who prescribed the Incivek. That person needs to be aware of all meds you are taking.
________________

Subutex is buprenorphine. Here is an FDA article that product labeling revisions for Incivek (Teleprevir)

It says "...no dose adjustment is needed for Incivek when given with either raltegravir or buprenorphine."
http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/ucm309863.htm
___________________________

Here is another:
The Effect of Telaprevir on the Pharmacokinetics of Buprenorphine in Volunteers on Stable Buprenorphine/Naloxone Maintenance Therapy

Co-administration of telaprevir did not increase withdrawal symptom frequency and there were no serious adverse events reported during or after completion of telaprevir co-administration.

===>>>Results suggest dose adjustment may not be necessary when telaprevir and buprenorphine/naloxone are co-administered.
http://aac.asm.org/content/early/2012/05/02/AAC.00077-12.abstract
_________________________-
Here is a table that shows (possible) drug interactions with Telaprevir/Buprenorphine

Telaprevir Metabolic Substrate: CYP 3A4 (major) into inactive and active metabolite (30 times less active than telaprevir)

Metabolic Inhibitor: CYP 3A4 - Substrate and inhibitor of P-gp (intestinal rather than systemic and would be saturable)

Buprenorphine Metabolic Substrate: CYP 3A4>2C8 (norbuprenorphine active metabolite), UGT 1A1 and other UGT (norbuprenorphine combination and its metabolites)

===>>>Significance: Non clinically significant interaction.

http://www.hivmedicationguide.com/details.asp?ID=9363&name=Telaprevir%20/%20Buprenorphine
Helpful - 0
Avatar universal
I'm currently taking pegasys injection, ribaviron, and incivek (the triple treatment) and am also taking subutex not suboxone. I need to know ASAP if this is okay to take can anyone please give me some basic info or an answer? I'm so desperately concerned about it as well as my own well being
Helpful - 0
568322 tn?1370165440
I disagree.

Suboxone contains four parts buprenorphine and one part naloxone.  And naloxone works by blocking opioid receptors ...just like naltrexone.

And it is a well known fact that the use of naltrexone is contraindicated with interferon because it COUNTERS some of the effects of interferon.

For example....Naloxone suppresses the rising phase of fever induced by interferon-alpha.  And fever during treatment is a good thing.  

I would do some more research if I was you.  Because although suboxone may be considered safe, it may also counter the effects from the med you want working at its best.  Naloxone can also increase liver enzymes and it can interfere with Telaprevir and Boceprevir if you're planning to use triple therapy.

Co
Helpful - 0
Avatar universal
I'm now on week 22 of my pegasys/riba therapy and been taking suboxone ever since and never had any problems. I would check with my physician however just to make sure
Helpful - 0
Avatar universal
thank you ive been a little worried about  taking them together, im sure before im done ill have more concerns its nice to get oppinions from other . thank you agian
Helpful - 0
87972 tn?1322661239
To my knowledge there aren’t any issues with concurrent use of suboxone and IFN therapy. Good luck with your treatment,

--Bill
Helpful - 0
Have an Answer?

You are reading content posted in the Hepatitis C Community

Top Hepatitis Answerers
317787 tn?1473358451
DC
683231 tn?1467323017
Auburn, WA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Answer a few simple questions about your Hep C treatment journey.

Those who qualify may receive up to $100 for their time.
Explore More In Our Hep C Learning Center
image description
Learn about this treatable virus.
image description
Getting tested for this viral infection.
image description
3 key steps to getting on treatment.
image description
4 steps to getting on therapy.
image description
What you need to know about Hep C drugs.
image description
How the drugs might affect you.
image description
These tips may up your chances of a cure.
Popular Resources
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.