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hepatitis C

if you have hepatits C how long does methadone stay in your system?
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Avatar universal
That is all very interesting ,however would you mind copying the links for those that may be interested in reading the articles( I'm not ,however someone may be) .
Very difficult to pull up by long titles.

Thx..
Will
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Avatar universal
Critical issues in the treatment of hepatitis C virus
infection in methadone maintenance patients
David M. Novick1,2,3 & Mary Jeanne Kreek1
Rockefeller University, New York, NY, USA,1 Kettering Medical Center, Kettering, OH, USA2 and Wright State University Boonshoft School of Medicine, Dayton,
OH, USA3


Addiction (2000) 95(12), 1771–1783
PRACTICAL BUSINESS OF TREATMENT
Population-based pharmacokinetic approach
for methadone monitoring of opiate addicts:
potential clinical utility
K. WOLFF1, A. ROSTAMI-HODJEGAN2, A.W.M. HAY3,
D. RAISTRICK4 & G. TUCKER2
1National Addiction Centre, Institute of Psychiatry, 2University of Shef. eld, Section of
Molecular Pharmacology and Pharmacogenetics, 3Research School of Medicine, University of
Leeds & 4Leeds Addiction Unit, Leeds, UK
Helpful - 0
Avatar universal
Critical issues in the treatment of hepatitis C virus
infection in methadone maintenance patients
David M. Novick1,2,3 & Mary Jeanne Kreek1
Rockefeller University, New York, NY, USA,1 Kettering Medical Center, Kettering, OH, USA2 and Wright State University Boonshoft School of Medicine, Dayton,
OH, USA3


Addiction (2000) 95(12), 1771–1783
PRACTICAL BUSINESS OF TREATMENT
Population-based pharmacokinetic approach
for methadone monitoring of opiate addicts:
potential clinical utility
K. WOLFF1, A. ROSTAMI-HODJEGAN2, A.W.M. HAY3,
D. RAISTRICK4 & G. TUCKER2
1National Addiction Centre, Institute of Psychiatry, 2University of Shef. eld, Section of
Molecular Pharmacology and Pharmacogenetics, 3Research School of Medicine, University of
Leeds & 4Leeds Addiction Unit, Leeds, UK
Helpful - 0
317787 tn?1473358451
I second the opinion, you always give great information and you explain it as well.  I remember being so sick I could not understand the scientific stuff and you explained, thank you so very much!!!
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163305 tn?1333668571
Wow, what a great answer, impressive research. I had no idea.
You're always being so helpful on the forum, clear answers with links to back you up.
Thanks~
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179856 tn?1333547362
Posting scientific data / studies with a post gives that post value and clarity since you know the person is not making it up or wording it incorrectly or is just a raving psycho or troll or know it all or something...

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Avatar universal
Anywhere from 30 to 120 hours
----------------------------------------

Please link studies on this and /or peer reviewed articles ,so as the rest of the group could peruse the info, for validity..
Thx..
Will
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Avatar universal
Anywhere from 30 to 120 hours.

Warm regards
Weezie MSN, RN
Helpful - 0
1747881 tn?1546175878
Excretion
The elimination of Methadone is mediated by extensive biotransformation, followed by renal and fecal excretion. Published reports indicate that after multiple dose administration the terminal half-life (T1/2) was highly variable and ranged between 8 to 59 hours in different studies. Since Methadone is lipophilic, it has been known to persist in the liver and other tissues. The slow release from the liver and other tissues may prolong the duration of Methadone action despite low plasma concentrations.

Hepatic Impairment
Methadone has not been extensively evaluated in patients with hepatic insufficiency. Methadone is metabolized by hepatic pathways, therefore patients with liver impairment may be at risk of accumulating Methadone after multiple dosing

http://www.drugs.com/pro/methadone.html
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