7593014 tn?1414212474

how long takes for interferon to show side effects?

I started today interferon ribavirin and sofosbuvir for 12 weeks.  When  the side effects appear  usaly what to expect? I am cirrhotic and genotype 3 with diabetes and background retinopathy
2 Responses
Avatar universal
Good luck with your treatment and hope your side effect symptoms are mild.or if not, at least tolerable.  

Do you know your pre-treatment Hemoglobin, Neutrophils and Platelets levels?  When they check blood levels if they give you a copy and/or tell you the results during the trial please let us know if possible and allowed. (maybe not with a trial).  But the important news you want to hear is viral load undetected in 4 weeks.  I have never been in a trial and don't know what info they give to patients or allow to be disclosed during the trial.or whether it varies depending on the trial.

Laboratory Abnormalities
Changes in selected hematological parameters are described in Table 4. A side-by-side tabulation is to simplify presentation; direct comparison across trials should not be made due to differing trial designs.

In the 12 wks tx less than 1% had Platelets below 50 (x109/L) vs 7% for 24 wks 23% had Hemoglobin <10 and only 2% <8.5  If Hemoglobin drops below 10 the recommendation is to lower ribavirin dosage.  Not sure about PEG

In the trials only 2% getting your tx had to quit because of adverse events but those who took the same for 24 weeks 11% had to stop

The proportion of subjects who permanently discontinued treatment due to adverse events was 4% for subjects receiving placebo, 1% for subjects receiving SOVALDI + ribavirin for 12 weeks, < 1% for subjects receiving SOVALDI + ribavirin for 24 weeks, 11% for subjects receiving peginterferon alfa + ribavirin for 24 weeks and 2% for subjects receiving SOVALDI + peginterferon alfa + ribavirin for 12 weeks.

FYI you mentioned background retinopathy don't get alarmed if you read this. It's a little bit technical and shouldn't be taken out of context. But in the very unlikely event you experience reduced visual acuity or other visual symptoms be sure to inform your treatment provider.

There is a growing body of clinical experience that it is safe to continue standard of care therapy with no dose reduction in patients who develop interferon-associated retinopathy so long as they do not have reduced visual acuity or other visual symptoms which would suggest the development of an atypical adverse event

To date, no definitive pathogenic link has been proven between antiviral therapy or interferon-associated retinopathy and any of the various atypical adverse events.
163305 tn?1333668571
If you do a simple google search on 'interferon side effects' you can see a huge list of possibilities.
The truth the side effects can range from slight to extreme.
The most common is fatigue, and flu like symptoms.

The best thing to do is drink lots of water, try to exercise and remember that you will feel better after the treatment is over.
Have an Answer?

You are reading content posted in the Hepatitis C Community

Top Hepatitis Answerers
317787 tn?1473358451
683231 tn?1467323017
Auburn, WA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Answer a few simple questions about your Hep C treatment journey.

Those who qualify may receive up to $100 for their time.
Explore More In Our Hep C Learning Center
image description
Learn about this treatable virus.
image description
Getting tested for this viral infection.
image description
3 key steps to getting on treatment.
image description
4 steps to getting on therapy.
image description
What you need to know about Hep C drugs.
image description
How the drugs might affect you.
image description
These tips may up your chances of a cure.
Popular Resources
Chlamydia, an STI, often has no symptoms, but must be treated.
For people with Obsessive-Compulsive Disorder (OCD), the COVID-19 pandemic can be particularly challenging.
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Here’s how your baby’s growing in your body each week.
These common ADD/ADHD myths could already be hurting your child
This article will tell you more about strength training at home, giving you some options that require little to no equipment.