From our liver transplant expert forum
http://www.medhelp.org/forums/Liver-Transplant/show/274
by Thomas D Schiano, MDBlank, Jul 28, 2011 06:44AM
despite the high viral load the liver biopsy findings are the most important thing in considering the necessity of anhtiviral treatment. our program is not using the new medications for fear of precipitating rejection and/or renal failure. These idrug nteractions are of major concern
by Thomas D Schiano, MDBlank, Jul 17, 2011 12:35PM
currently there is no data on its use in the post-liver transplant setting. i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
by Thomas D Schiano, MDBlank, Jul 20, 2011 07:54AM
the new medications may affect the dose of prograf dramatically, possibly up to 70%. this might make it difficult to control the levels and predispose the person to rejection or renal failure. there are very early studies looking at this. our center is not starting patients on therapy except if someone has a fulminant course of recurrence until more data are available. i am sure that other centers however will embrace the new meds and will be actively treating patients with them.