Aa
nitazoxanide for Hep C Genotype 4 relapser
I'm just looking for people with same condition want to share information -- in particular about nitazoxanide for treatment-experienced genotype 4 hep c patients, but also of any other options that may be available.
For instance I've heard of
1. prolonged 72-week standard treatment.
2. increased dosage of 2g/day of nitazoxanide.
3. new drug coming out next year -- don't remember the name.
Thanks
For instance I've heard of
1. prolonged 72-week standard treatment.
2. increased dosage of 2g/day of nitazoxanide.
3. new drug coming out next year -- don't remember the name.
Thanks
Hi there fellow GT4.
Few questions:
- what is your current VL and in what range does it flactuate ?
- what is your fibrosis level ?
- how long are you infected ?
- did you check if you are insulin resistant (geno4s with high VL are very prone to IR)?
- do you know your ferritin level ?
- what was your Riba dose on first tx ?
If I were to start over right now this would be my protocol:
1) get Vit D level up.
2) start taking Alinia 500mg BID for 3 weeks
3) add Ribavirin weight based for another 2 weeks
4) add Pegasys this time and double dose first shot
3) keep taking all meds until EOT
5) do a 2wk PCR
6) try and get a hemoglobin drop of >3g early on
Again that`s what I would do if I could turn back time.
Teleparvir did not show as strong antiviral activity for GT 4 as for GT1.
Were it available would I try it , propably but I decided not to wait for it.
The next best thing is RG7128. If you want to wait I would see if there
is a phase 3 RG7128 that includes geno 4 relapser
b
Few questions:
- what is your current VL and in what range does it flactuate ?
- what is your fibrosis level ?
- how long are you infected ?
- did you check if you are insulin resistant (geno4s with high VL are very prone to IR)?
- do you know your ferritin level ?
- what was your Riba dose on first tx ?
If I were to start over right now this would be my protocol:
1) get Vit D level up.
2) start taking Alinia 500mg BID for 3 weeks
3) add Ribavirin weight based for another 2 weeks
4) add Pegasys this time and double dose first shot
3) keep taking all meds until EOT
5) do a 2wk PCR
6) try and get a hemoglobin drop of >3g early on
Again that`s what I would do if I could turn back time.
Teleparvir did not show as strong antiviral activity for GT 4 as for GT1.
Were it available would I try it , propably but I decided not to wait for it.
The next best thing is RG7128. If you want to wait I would see if there
is a phase 3 RG7128 that includes geno 4 relapser
b
Thank you all. I've selected the best answer, and really wanted to select the other too, but the best implies there must be only one.
Thanks again.
Thanks again.
4d, I was genotype 1, but I believe there is at least one forum member that would be interested in info exchange for GT-4.
Try Bali:
http://www.medhelp.org/personal_pages/user/979080
The drug you might be referring to that will hopefully be approved and released for general use is ‘Telaprevir’, by Vertex Pharmaceuticals. This is one of a new class of meds collectively called ‘STAT-C’ (Specifically Targeted Antiviral Therapy); there are many others behind this, but it’s likely this will be first in line for approval.
Good luck—
--Bill
Try Bali:
http://www.medhelp.org/personal_pages/user/979080
The drug you might be referring to that will hopefully be approved and released for general use is ‘Telaprevir’, by Vertex Pharmaceuticals. This is one of a new class of meds collectively called ‘STAT-C’ (Specifically Targeted Antiviral Therapy); there are many others behind this, but it’s likely this will be first in line for approval.
Good luck—
--Bill
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There is one member here, Bali, who is very knowledgeable, is a genotype 4 and is currently treating.
He really put all his ducks in a row before starting treatment and reserached G-4's to every extent possible, although you are probably aware that the pickings are slim for G-4 studies.
Here's his profile page and I'd suggest you either send him a note or a private message or better yet, both:
http://www.medhelp.org/personal_pages/user/979080
I encourage you to contact him, as he's a wealth of both knowledge and experience. I think he pre-dosed riba but can't remember if he took alinia (nitazoxanide) or at some point considered it.
Quite a few people on this board have relapsed. Susan400 has done treatment upwards of ten times and remains hopeful for her next try. Andiamo treated ten or eleven times and succeeded by adding the new Stat-C drugs.
What were your last biopsy results?
Best wishes and my sincere regrets about your relapse.
Susan