.The package insert simply says take with food , no designation as to how much or what, follow the link to see more on the subject.
Congrats to you ! What a feat ! You are brave ! I have 4 more days on inc , and counting down the hours. Prayers for Great Labs !
There have been several studies that showed the bioavailability of ribavirin increased with a high fat meal. The question is how much fat. My guess is to take with some fat (10 g?), not the 20 g needed for Inc. This has been discussed frequently on the forum if you care to search more.
Effect of Food on Absorption of Ribavirin
Bioavailability of a single oral dose of Ribavirin was increased by co-administration with a high-fat meal. The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when Ribavirin tablets were taken with a high-fat meal compared with fasting conditions [see Dosage and Administration (2.1) and Patient Counseling Information (17)].
My nurse told me to take it with a substantial meal or it can cause nausea.
Effect of food on absorption of ribavirin:
Both AUC and C-MAX increased by seventy percent when Rebetol Capsules were administered with a high fat meal: (841 kcal, 53.8 g fat, 31.6 g protein, and 57.4 g carbohydrate) in a single-dose pharmacokinetic study
If you do the math you will have to eat 26.9 grams of fat for a 35% increase in absorbtion
These are often single dose studies and don't relate directly to our daily regime of Ribavirin dosing. The point is, there is an increase in absorption when taking ribavirin with a high-fat meal compared to fasting or a normal meal. I'm not suggesting to maximize absorption by eating unhealthy amounts of fat.
I try to eat some fat with my ribavirin, but don't worry about counting grams. If I can do something simple to slightly increase the absorption, then why not. Now, if my Hgb was consistantly below 10, then I might reconsider.