Aa
A
A
A
Close
Hepatitis C Community
13.4k Members
Avatar universal

ribavirin and food?

I will be done with my incivek tomorrow and will be so grateful I don't have to take it anymore and the high fat meal/snack before each dose.
My question is, do you need to eat anything before taking ribavirin?
8 Responses
1747881 tn?1546179478
.The package insert simply says take with food , no designation as to how much or what, follow the link to see more on the subject.

http://www.medhelp.org/posts/Hepatitis-C/Starting-Week-12-on-INC---THEN-WHAT-/show/1637168 .
1794638 tn?1345158661
Congrats to you !     What a feat !    You are brave !   I have 4 more days on inc , and counting down the hours.    Prayers for Great Labs !  
1669790 tn?1333666195
There have been several studies that showed the bioavailability of ribavirin increased with a high fat meal.  The question is how much fat.  My guess is to take with some fat (10 g?), not the 20 g needed for Inc.  This has been discussed frequently on the forum if you care to search more.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1804105/

Effect of Food on Absorption of Ribavirin

Bioavailability of a single oral dose of Ribavirin was increased by co-administration with a high-fat meal. The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when Ribavirin tablets were taken with a high-fat meal compared with fasting conditions [see Dosage and Administration (2.1) and Patient Counseling Information (17)].

http://www.drugs.com/pro/ribavirin.html

163305 tn?1333672171
My nurse told me to take it with a substantial meal or it can cause nausea.
1747881 tn?1546179478
http://www.spfiles.com/pipeg-intron.pdf

Effect of food on absorption of ribavirin:

Both AUC and C-MAX increased by seventy percent when Rebetol Capsules were administered with a high fat meal: (841 kcal, 53.8 g fat, 31.6 g protein, and 57.4 g carbohydrate) in a single-dose pharmacokinetic study

If you do the math you will have to eat 26.9 grams of fat for a 35% increase in absorbtion
1669790 tn?1333666195
These are often single dose studies and don't relate directly to our daily regime of Ribavirin dosing.   The point is, there is an increase in absorption when taking ribavirin with a high-fat meal compared to fasting or a normal meal.  I'm not suggesting to maximize absorption by eating unhealthy amounts of fat.  

I try to eat some fat with my ribavirin, but don't worry about counting grams.  If I can do something simple to slightly increase the absorption, then why not.  Now, if my Hgb was consistantly below 10, then I might reconsider.  
Have an Answer?
Top Hepatitis Answerers
317787 tn?1473362051
DC
683231 tn?1467326617
Auburn, WA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Answer a few simple questions about your Hep C treatment journey.

Those who qualify may receive up to $100 for their time.
Explore More In Our Hep C Learning Center
image description
Learn about this treatable virus.
image description
Getting tested for this viral infection.
image description
3 key steps to getting on treatment.
image description
4 steps to getting on therapy.
image description
What you need to know about Hep C drugs.
image description
How the drugs might affect you.
image description
These tips may up your chances of a cure.
Popular Resources
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Here’s how your baby’s growing in your body each week.
These common ADD/ADHD myths could already be hurting your child
This article will tell you more about strength training at home, giving you some options that require little to no equipment.
In You Can Prevent a Stroke, Dr. Joshua Yamamoto and Dr. Kristin Thomas help us understand what we can do to prevent a stroke.
Smoking substitute may not provide such a healthy swap, after all.