I would suggest that your brother-in-law handle his own medications. Many of us set alarms to remind us of taking our pills and no one is dispensing them to us. HCV treatment can take on a certain drama and it may not be working out well in his household. The women may also be somehow physically exposed to the medications. Put them all away in a secure place and encourage the women to support the therapy by keeping him company,seeing to his exercise and dietary needs, and empathizing with his fatigue. I think they'll be happier and healthier if they come out of the medication loop.