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sovaldi and olysio relapse in first week EOT


On October 22, I finished Sovaldi and Olysio. My energy had returned initially, but now I am feeling exhausted again in the afternoon. I do have fear that the virus has returned because of this and other symptoms. My doc said the virus usually returns in the first few days. He also said that it can return after that time frame.
I would appreciate if relapsers on S and O would share how soon after EOT did the virus returned?

Many thanks in advance!!

16 Responses
317787 tn?1473362051
Dear Mary, I think we all go through this where we think we have relapsed.  After finishing tx we feel like we can begin life again.
In many cases we do too much too soon and so we wear ourselves out.
Try to continue drinking lots of water, take rests when  your body is tired.
Hang in there. I am going to try to find you a post about other people who did the same treatment.  I did not take this regimen but there are many here who did.  P.S. The first time I treated and relapsed it happened in the first 4 weeks.
My best to you, Dee
Avatar universal
Mary:  I have read several posters, both on the Sol/Oly and on the Sol/ Riba who felt that way after treatment and still SVR'd.  As they were told, you must remember that your body is still clearing those extremely powerful meds, so you are probably going through some withdrawal.

I finished my Sol/Riba 12-1 and have already experienced an episode where I felt like I did during the 5th week of treatment .  Thanks to heads ups, I am trying not to stress and just wait for the test - my Dr did EOT (will get the results the 17th) and then not until EOT Wk 12.

As Dee said, drink your water.  It is amazing what proper hydration does for the body!

Hang in there and breathe deeply, rest often, and try to keep your mind occupies so you don't stress so much.  Pat
Avatar universal
Mary, i don't Know if my post will help you, the way you feel is so normal and all you want is to feel great but ..,,it takes time.

I finished sol /rib treatment , I'm at 14 weeks end of treatment , I got a confirmation that I'm SVR 12 weeks !!! And I don't feel like I want to feel. For the last week I have headache and a few nights had fever with chills and sweats. I'm fighting a virus but the nurse reasure me it wasn't hepc .... Strange but for me EOT was almost harder than the treatment itself . I had to take a month off work at the end. I felt like I had withdrawal symptoms ?!? So much fatigue and My anxiety was very high. I know it is easy to say but try to not focus to much on the relapse . I was so stress and scare I decided to seek help.  Today in my mind I know I'm SVR and I'm still afraid for the next blood work at week 24. So hang in there, it will get easier slowly .
Avatar universal
I relapsed immediately from S&O and I knew it.My doc said I was his only relapse.I am geno type 1a stage 4 cirrhosis and a lifetime non responder of everything that has been available so it came as a big surprise when for the first time since I started taking all these poisons in the mid 80s that I cleared but it was no surprise when I immediately relapsed.If you are 1a that could be the reason for the relapse,we are the hardest to heal.Hang in there and get on board with the new stuff that is coming out.I am trying to get Harvoni but my battle has been a losing one.My insurance says that since I failed with S&O I will fail with Harvoni so why bother.Gilead is also having me jump through hoops like a circus dog with no end to their desires.Getting to worn out to continue the fight but you must.
                          Good Luck   Glen
Avatar universal
Can you appeal what your insurance's decision? Show them this article:

Ann Intern Med. 2014 Nov 4
Re-treatment of Chronic Hepatitis C Virus Genotype 1 Infection After Relapse: An Open-Label Pilot Study.
Osinusi A, Kohli A, Marti MM, Nelson A, Zhang X, Meissner EG, Silk R, Townsend K, Pang PS, Subramanian GM, McHutchison JG, Fauci AS, Masur H, Kottilil S.


The interferon (IFN)-free regimen of sofosbuvir and ribavirin for 24 weeks was recently approved to treat chronic hepatitis C virus (HCV) genotype 1 (GT-1) infection for patients ineligible for IFN. However, sofosbuvir plus ribavirin therapy is associated with relapse in 15% to 30% of patients with HCV GT-1. Neither the mechanism of relapse nor the optimal re-treatment strategy for these patients is defined.
To assess the safety and efficacy of sofosbuvir plus ledipasvir in patients with chronic HCV GT-1 that relapsed after sofosbuvir plus ribavirin therapy.
Phase 2a, open-label study. (ClinicalTrials.gov: NCT01805882).
Single U.S site.
14 patients with HCV GT-1 that relapsed after treatment with sofosbuvir plus ribavirin for 24 weeks were re-treated with sofosbuvir plus ledipasvir for 12 weeks.
HCV RNA concentration and population sequencing to detect NS5B S282T mutations.
All 14 patients treated with sofosbuvir plus ledipasvir for 12 weeks achieved a sustained virologic response, including 7 with advanced liver disease (Knodell Histology Activity Index score of 3 or 4) and 1 with a detectable NS5B S282T mutation after sofosbuvir plus ribavirin therapy. Sofosbuvir plus ledipasvir was well-tolerated with few adverse events. Four grade 3 events (elevated serum creatinine in a patient with baseline renal insufficiency, hypercholesterolemia, and hypophosphatemia) occurred. There were no grade 4 events or treatment discontinuations.
Small sample size.
The fixed-dose combination of sofosbuvir plus ledipasvir was efficacious in a small cohort of patients with HCV GT-1 that relapsed after sofosbuvir plus ribavirin therapy, even in the setting of advanced liver disease. Larger studies are needed to confirm these preliminary efficacy results.
National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Cancer Institute, and Gilead Sciences.
Avatar universal
Also, if that doesn't work, the Abbvie drugs will be approved in the next week or two. I was a cirrhotic 1a, previous non-responder to everything and the Abbvie drugs cleared me and I have been SVR for over a year now. Abbvie has promised us that they intend to work seriously to make sure everyone who wants it can treat with their drugs. If you do go that route, I would insist on 24 weeks if possible. Good luck.
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