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treatment reeking havoc on liver

I have 3a geno found out in 03 biopsy grade3 fibrosis, started pegintron-reb treatment in 07, week 6 of 24 bloodwork shows virus undetectable and my viral load was 60mill but alt-ast afp- alkaline phosphate all rising fast?  also my wbc-platlets dropped like a rock had to start nuepogen shots , doc pulled me of tx for 2weeks got back on tx but could not do the nuepogen side effects couldnt hang, my alt-ast have always been triple what they should be since 03 but on tx they triple even more my doc thinks im dealing with a resistant virus. doc pulls me off treatment 11 of 24weeks in and 4 weeks later virus is back 12 weeks alt-ast lower than normal around 80s afp and al-phosphate all back to normal, now i have decided to try the tx again this time i am starting nuepogen before tx so far so good wbc staying up but my platlets are 55 and im 13of24 weeks in halfway baby but here is the big problem again ALT-AST 300 AGAIN WHAT THE HELL IS GOING ON HERE IS THE TX HURTING MY LIVER THESE ENZYMES SHOULD BE GOING DOWN IM GETTING VERY DISCOURAGED, PLEASE HELP? THANKS EDWARD
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808544 tn?1248686419
I too am a 3a grade 3 fibrosis. I am now 18 wks into 2nd round tx and achieved UND at 12wks. My 1st round 48wks UND @ 14wks stayed there all thru tx then 3mos post virus was back. I think I am dealing with a resistant one also so Dr. recommended 72wks I am lucky not to have bad sides but these ALT-AST #s you have seem very high and I will be waiting to see what others have to say. My last lab mine were 54/ast 60/alt up slightly from last lab. My nurse said not to worry but I'm not sure why it went up.
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Avatar universal
I believe some poeple develop auto immune hepatitis from treatment. The symptoms can include rising liver enzymes in the presence of undetectable virus levels during treatment. I would believe your doctor could address this better but in the pubished report I read by Dr. SHeik of UPMC they did a biopsy to detemine that the cuase was autoimmune hepatitis in this patient.

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Avatar universal
hey duke, yes i was checked for auto immune hep back in 2007 when the same thing was happening on tx, it was done by blood work not a biopsy, maybe i should get another biopsy done after tx and platelets go back up enough .
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