No. You wouldn't supplement your diet with vitamin E based on a single animal study. Nobody takes drugs based on animal studies. There need to be controlled studies in human with the particular illness before you can have any idea what you're doing.
I agree with you that the article is hard to follow. It appears it is advising AGAINST the use of Vitamin E before, during and immediately after PH surgery because of a complex process in which anti-oxidant properties interfere adversely.
You might find this interesting:
Treatment with silybin-vitamin E-phospholipid complex in patients with hepatitis C infection.
Falasca K, Ucciferri C, Mancino P, Vitacolonna E, De Tullio D, Pizzigallo E, Conti P, Vecchiet J.
Clinic of Infectious Diseases, Department of Medicine and Science of Aging, G. d'Annunzio University, Chieti-Pescara, Italy.
The aim of this study was to evaluate the hepatoprotective and anti-inflammatory effects of silybin-phospholipids and vitamin E complex (SPV complex), by determining cytokine patterns and various markers of liver disease. Forty Caucasian patients with chronic HCV infection were recruited and divided into two groups: 30 were treated with SPV complex for 3 months, while the other 10 did not receive any treatment. Ten other subjects without HCV infection but with staeatosic diagnosis were recruited and treated with SPV complex. Biochemical and hepatic principal parameters were investigated at 0 (T0) and 3 months (T3). The group of HCV patients treated showed an improvement trend of hepatic indecises and viral load, and had a significant and persistent reduction of ALT (P = 0.02) and AST serum level (P = 0.01). In this group cytokines showed a statistically significant increase of IL-2 (P = 0.03) and IL-6 were significantly reduced (P = 0.02) at T0 and T3. After the treatment the group of hepatic steatosics showed a significant decrease in ALT (P = 0.02), AST (0.008), gammaGT (0.004) alkaline phosphatase (0.05), total cholesterol (P = 0.03), fasting glucose (P = 0.008), insulinemia (0.0006), HOMA value (0.002) and C-reactive protein (CRP; 0.04). There was a significant reduction of IFN-gamma, TNF-alpha, and IL-6 (P = 0.02, 0.05 and 0.04, respectively). The data suggest that the SPV complex exerts hepatoprotective, anti-inflammatory and antifibrotic effects. This new compound may therefore be useful in clinical practice in patients with chronic hepatitis C who cannot undergo conventional antiviral therapy. 2008 Wiley-Liss, Inc.
Falaska, K. et. al. (2008, Nov.). Treatment with silybin-vitamin E-phospholipid complex in patients with hepatitis C infection. Journal of Medical Virology, 80(11):1900-6. Retrieved March 1, 2009 from http://www.ncbi.nlm.nih.gov/pubmed/18814247.
And here's another one, in case we haven't posted this recently, that discusses the utility of Vitamin E to prevent inflammation in patients undergoing Tx for Hep C. The sample size is really small, however (30), and more research is needed.
Vitamin E and C supplementation prevents decrease of eicosapentaenoic acid in mononuclear cells in chronic hepatitis C patients during combination therapy of interferon alpha-2b and ribavirin.
Murakami Y, Nagai A, Kawakami T, Hino K, Kitase A, Hara Y, Okuda M, Okita K, Okita M.
Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectual University, Okayama, Japan.
OBJECTIVE: We investigated the effects of vitamin E and C supplementation on the fatty acid composition of mononuclear cells and on the clinical observations in patients who had chronic hepatitis C and received interferon-alpha-2b (IFN-alpha-2b) and ribavirin combination therapy.
METHODS: Patients were randomly allocated to receive daily 500 mg of vitamin E and 750 mg of vitamin C (vitamin group, n = 14) or no supplement (non-vitamin group, n = 16) in addition to IFN-alpha-2b and ribavirin therapy. The fatty acid composition of mononuclear cell phospholipids was analyzed before and at 2, 4, and 8 wk after treatment.
RESULTS: After vitamin supplementation, plasma and red blood cell alpha-tocopherol and plasma ascorbic acid levels increased in the vitamin group. Serum levels of alanine aminotransferase decreased significantly after 2 wk of treatment in both groups. At the start of treatment, a lower level of eicosapentaenoic acid (EPA) and a higher level of the molar ratio of arachidonic acid to EPA in mononuclear cells were observed in the present patients compared with healthy volunteers, and a significant correlation between the molar ratio and serum alanine aminotransferase level was found. The EPA level of mononuclear cells was maintained in the vitamin group during treatment, whereas a significant decrease was observed in the non-vitamin group at 4 and 8 wk after treatment.
CONCLUSIONS: Antioxidant vitamin supplementation during IFN-alpha-2b and ribavirin therapy prevented a decrease in EPA of mononuclear cell phospholipids. If a further decrease in the ratio of arachidonic acid to EPA can be achieved by using oral EPA supplementation, the efficacy of IFN-alpha-2b and ribavirin therapy may be improved.
Murakami Y, Nagai A, Kawakami T, et al. (2006) Vitamin E and C supplementation prevents decrease of eicosapentaenoic acid in mononuclear cells in chronic hepatitis C patients during combination therapy of interferon alpha-2b and ribavirin. Nutrition, 22(2):114-22. Retrieved March 1, 2009 from http://www.ncbi.nlm.nih.gov/pubmed/16459223.
Thanks m-strings. The studies you posted are more timely and relevant to pre-tx and tx.
I'm taking the vitamin e.
Marc/portann...If my rat's liver ever needs partial removal, I won't give him any e. Thanks for interpreting.
I'm learning a new language, reluctantly.
Well, I'm not an MD, but would advise you to take it only as directed and make sure to consult w/your medical team. Here's to you and your rat's good health! ;>)
Thank you very much for printing those articles. My husband (with cirrhosis) is on his 3rd tx try with peg/Alinia and has been on it since the 1st of June and is still not nondetectible. His last viral load was 495 and has been in this neighborhood for several months. Because he is at the desperate stage, they have allowed him to switch to daily infergen and I am reviewing the supplements I give him . These articles were very helpful in making my mind up about including vit E.
i don't know, i would be careful with fat soluble vitamins, they're not that easily excreted out of the body like water soluble ones guess it's ok as long as you don't exceed the RDA
Lalapple has a point re: fat soluble vitamins, which are stored longer in the liver and fatty tissues. I'm always a fan of getting Vitamin E through natural foods, such as fruits and green, leafy vegetables, grains, nuts, seeds. Again, I'd consult with your doctors. The studies are interesting and look promising! They are not comprehensive however, and do not consider longer-term outcomes.
Evangeline: Thanks for your comments. I wish the best to your husband. His viral load is getting down there. It sounds like he's really fighting. I sure hope they can wipe it out! I'm glad you found the articles useful! I'm praying for you!!