Aa
It's not a good thing.
"Non-alcoholic steatohepatitis (NASH) is a form of chronic hepatitis with histological features of alcohol-induced liver disease that occurs in individuals who do not consume significant amounts of alcohol.[1] Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of clinicopathological syndromes with varying risks of cirrhosis. The probability of developing advanced hepatic fibrosis is significantly greater in individuals with steatohepatitis than in those with simple steatosis.[2-4] Between 15 and 20% of patients with steatohepatitis develop cirrhosis over one or two decades.[2,4] Although lipid lowering agents like statins and fibrates, antioxidants like vitamin E, insulin sensitizing agents like metformin, and cytoprotective agents like ursodeoxycholic acid (UDCA) have shown some promise by reducing the levels of aminotransferases, and in a few studies improvement in liver histology; none of these drugs can be recommended as a targeted and specific therapy for NASH. Most of the studies in this area have been small, non-randomized and did not have any follow-up histological studies.
We have recently reported the beneficial effects of 6 months of pentoxifylline therapy in clinical, biochemical and metabolic parameters in patients with NASH.[5] The present study reports the observations on the same cohort of patients treated for 12 months. The special feature of this study is the histological evaluation after completion of the therapy."
From: http://www.medscape.com/viewarticle/559029_1
Mike
"Non-alcoholic steatohepatitis (NASH) is a form of chronic hepatitis with histological features of alcohol-induced liver disease that occurs in individuals who do not consume significant amounts of alcohol.[1] Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of clinicopathological syndromes with varying risks of cirrhosis. The probability of developing advanced hepatic fibrosis is significantly greater in individuals with steatohepatitis than in those with simple steatosis.[2-4] Between 15 and 20% of patients with steatohepatitis develop cirrhosis over one or two decades.[2,4] Although lipid lowering agents like statins and fibrates, antioxidants like vitamin E, insulin sensitizing agents like metformin, and cytoprotective agents like ursodeoxycholic acid (UDCA) have shown some promise by reducing the levels of aminotransferases, and in a few studies improvement in liver histology; none of these drugs can be recommended as a targeted and specific therapy for NASH. Most of the studies in this area have been small, non-randomized and did not have any follow-up histological studies.
We have recently reported the beneficial effects of 6 months of pentoxifylline therapy in clinical, biochemical and metabolic parameters in patients with NASH.[5] The present study reports the observations on the same cohort of patients treated for 12 months. The special feature of this study is the histological evaluation after completion of the therapy."
From: http://www.medscape.com/viewarticle/559029_1
Mike
Is that real bad or just something they treat..I feel so dumb asking that question
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