Hector
Thanks for your reply. I hope you are doing OK
Pete
As far as platelet counts...
This is from the PEGASYS (peginterferon alfa-2a) Package Insert -
"Dose reduction to 90 µg PEGASYS is recommended if the platelet count is less than 50,000 cells/mm3.
Cessation of therapy is recommended when platelet count is below 25,000 cells/mm3."
Ultimately it is really up to your treating doctor and what they are comfortable with.
For us cirrhotics for example, instead of stopping we will be given by our hepatologist either a platelet transfusion or Promacta when our platelet count drops below 25,000 or 20,000 because if we don't clear the virus, it may be our last shot at treatment before we are too ill to treat our HCV.
By the way, you have plenty of platelets so there is no danger as far as clotting and bleeding. Unless you have other coagulation issues which would be seen by your INR test results.
If your platelet counts gets very low you will notice intermittent nose bleeds that take a long time to stop and bleeding gums after brushing teeth. You may also bruise more easily and notice little dots of blood under your skin. I've experienced all this and while not usually a serious issue you should mention it to your doctor. Many of cirrhotics normally have platelets in the 50s-60s for years with no issues. I've had platelet counts in the 50,000s for over 5 years.
I'll let others comment on WBCs.
Cheers!
Hector