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190885 tn?1333029491

zoloft question

i tried paxel...that just plan didn't work...now they gave me zoloft...100 mil..i cut them in half taking half a day...took it 3 days ago...then once each day...i'm stoned off of them...really sleepy ...is this normal??? i could sleep anywhere...anytime...my heart check up went great...no problems at all...i want to start tx in like 3 months or so...will this fatigue go away in a week or so...makes me wonder how many zombies are out there driving around eating this stuff like candy...i just want to head off mental trouble while on tx.....thanks...billy
17 Responses
Avatar universal
"didn't work"

Work what?  Why are you taking these meds?
Avatar universal
It should get better with time. Give it a good try. If you are still too sleepy after several weeks, you can always reduce the dose.

Does it help your depression? When I was depressed, I didn't sleep for weeks, just couldn't. So I welcomed being sleepy. I took Paxil for 5 years and then got off it. There were some side effects in the first weeks, but everything got back to normal eventually. My mood was a little "flat" (usually I get excited and nervous about things), but I didn't mind that.

Why Paxil didn't work for you?
1491755 tn?1333204962
Zoloft 50 mg worked for me during tx, I am down to 25mg getting off of it, then i am going to take 12.5mg for a few weeks.  I guess I never noticed if it made me more tired or not, I always assumed it was the inf or the riba.

It is supposed to take two weeks for full effect.
1477908 tn?1349571310
Sometimes we have to tweak with brands and dosages before we find something that works for us. And also dosage times. Do you take yours before bedtime?

AD's had the opposite effect on me - getting me all hyper, so nightime doses were out of the question and even during the day, left me feeling edgy. Citalopram (Celexa) finally was the one that worked for me, and still on low doses and in the morning.

At least with the 3 months before tx starts, you'll be able to balance things out.
Good luck to you, Pam
Avatar universal
Sleepy is the expected effect of these drugs. They inhibit the removal (uptake) of the chemical Seratonin. This is the brain chemical that "makes you sleepy". You probably find yourself yawning all the time.

Oddly enough, as others have mentioned, sometimes these same drugs make you tense and give you insomnia.

Go figure.

Most other people notice that they make you feel kind of dull emotionally - not really happy or sad, just kind of "stable". I don't think anyone really knows how this stuff works.

1253246 tn?1332076910
Antidepressants are of three main types

   1. Monoamine oxidase inhibitors - MAOIs
   2. Selective serotonin reuptake inhibitors - SSRIs
   3. Tricyclics - TCAs
Trial and error and you should find one thats works well for you.Or maybe adjust the dosages.Some people take a combination of 2 antidepressants.
475300 tn?1312426726
Billy, I take Zoloft also.  I did not start aat vthat high of a dose.  I forget what dose, maybe 50mgs maybe less.  They do not make me tired at all bbut we are all different.

I now take 125 mgs and they work OK.
Avatar universal
Hi Billy,

I think it is a common side effect from the people I know who have used it, but as denise said people experience it differently. If you just recently started taking it you will very likely adjust to it.

Glad to hear your heart check up went well.


"ZOLOFT can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how ZOLOFT affects you."
1636196 tn?1337804900
  i to take zoloft it has taken about three weeks to set in 50ml once a day sleep what is that it is even worst after tx and 0-to-rage is the pits barbs jack me up out of all the barbs the big z works a little better than most becareful barbs are addicting
190885 tn?1333029491
i just got up at 9am!! lots of sleep...i'll take it at night before bed...maybe that will help..right now i'm sleepy all the time though...i'm not depressed i'm doing this because i don't want to get freaky during tx...i'll give it a few weeks...one of my daughters who is a nurse practitioner said i maybe should try celexa like paen53 suggested...anyway thanks guys.....billy
Avatar universal
  Hi Billy....You say right now you are not depressed and that you don"t want to get "freaky" during tx.

I was just wondering why your Dr. thought you should go on a fairly strong  AD when you are not depressed and you are still 3 months away from treating,

The SSRI  that you are taking  come with some possible side effects, both long and short term  and if you have no history of depression ,was just wondering if you and the doc are jumping the gun a little...especially given the sleepy thing.


148588 tn?1465782409
Starting IFN patients on an SSRI a *couple weeks* before starting tx has long been a CYA protocol used by *some* doctors. Starting a patient with no history of depression several months before tx - not so much.
Starting off with a cheap, generic, easy to wean off of SSRI, with a long history of safety/efficacy, like Prozac(fluoxetine) makes sense to me. Starting with high $, high powered, brand names that are diffucult to stop taking - again, not so much.
Part of the rationale for doing triple drug tx (along with the higher probability of SVR) is that given a favorable IL28B and a favorable rapid response, you could shorten tx time and possibly eliminate the need for helper drugs.
It's your brain stem function you're modifying. You do what makes you feel comfortable.
Avatar universal
Hey billy, you're doin' it wrong.
Avatar universal
That must be some good coffee you're drinking there :)
Avatar universal
I didn't get depressed during treatment. I was pretty much fine until about 8 months when I started having some major sudden mood springs. Luckily my sweet wife didn't leave me.
- Dave
1636196 tn?1337804900
I had a docter appointment today with the pychs the big z at 50 ml was purfect but they move me to 100 ml I'll cut them in have I don't know when I'll re start tx still need to talk to the hep doc I am a little scared about moods swings the doc today told me that zoloft is a little easyer on the liver I will have  see if it true I was really sleepy at first
Avatar universal
For anyone who is considering becoming pregnant after completing treatment and is still using Zoloft.

Based upon current scientific and medical research regarding Zoloft and its effects during pregnancy, the drug has been determined to be potentially harmful to the fetus during development. The anti-depressant has been classified by the U.S. Food and Drug Administration (FDA) as a Category C drug during pregnancy. Although the drug may be determined necessary and prescribed by a physician during a pregnancy, there are several risks which should be considered. Also, if you are trying to become pregnant or become pregnant while taking the medication, please consult with your doctor.

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