Aa
What if??????
Hey Guys,
I was just wondering about the SOC for this disease. What do you think of the possibly that if a person keeps retreating with interferon and ribavarin that eventually they will become resistant to the drug(s) because of numerous retreatments/trys? Do you think that it's possible? A tolerance level build up? I know that it's true to HIV medications that one's system does eventually build a resistance to the meds and thereby one has to change to other cocktails/drugs.
If that's the case then for non's and relaspers, then should the FDA approve VX-950 to be used along with the SOC of interferon and ribavarin be it whatever dosage or form, wouldn't it stand to reason that the VX-950 wouldn't be effective at all, because it has to be used along with those drugs that you've now become resistance to? If so, then the bottom line would be what then outside of tranplantation.
Any insight on this? Has there been any discussion on this board about this? It will be something that I definitely will ask my treating Dr. and let you guys know.
In Him,
R
I was just wondering about the SOC for this disease. What do you think of the possibly that if a person keeps retreating with interferon and ribavarin that eventually they will become resistant to the drug(s) because of numerous retreatments/trys? Do you think that it's possible? A tolerance level build up? I know that it's true to HIV medications that one's system does eventually build a resistance to the meds and thereby one has to change to other cocktails/drugs.
If that's the case then for non's and relaspers, then should the FDA approve VX-950 to be used along with the SOC of interferon and ribavarin be it whatever dosage or form, wouldn't it stand to reason that the VX-950 wouldn't be effective at all, because it has to be used along with those drugs that you've now become resistance to? If so, then the bottom line would be what then outside of tranplantation.
Any insight on this? Has there been any discussion on this board about this? It will be something that I definitely will ask my treating Dr. and let you guys know.
In Him,
R
zazza/all
That makes sense, Logical. After I thought about it, I started thinking inteferons aren't like antibiotics, which I think you can become immune too. Inteferons are produced by the liver naturaly. So other than a really unusual rection, it didn't make sense to me.
I think I am at where you said about PI, I am on Infergen, and I am begining to think it is poisioning me. My RBCS and WBCs and have crashed while on neupogen and just re started procrit. My 4 week VL actually went up, I am know waiting for VL to come back.
You just gave me something to think about, thanks!
Deb
That makes sense, Logical. After I thought about it, I started thinking inteferons aren't like antibiotics, which I think you can become immune too. Inteferons are produced by the liver naturaly. So other than a really unusual rection, it didn't make sense to me.
I think I am at where you said about PI, I am on Infergen, and I am begining to think it is poisioning me. My RBCS and WBCs and have crashed while on neupogen and just re started procrit. My 4 week VL actually went up, I am know waiting for VL to come back.
You just gave me something to think about, thanks!
Deb
My personal take on this is that we don't get resistant against interferon and ribavirin. These drugs are not directly aimed at the virus. Interferon increases our immune response, and what ribavirin does we really don't know.
The protease inhibitors are however directly aimed at the virus, so we get resistant to them. That is why non-responders need to think very carefully before retreating with PIs. They might need to add more than a PI to the mix in a future tx. So if we are non-responders and perhaps even just partial responders, maybe we should wait for other PIs and polymerase inhibitors to be approved. Worth thinking about.
As to "the first time you treat are the best results", I have wondered about this also. I think it might be that having relapsed or non-responded once, you know that you are not in the percentage easily cured. That is all.
The protease inhibitors are however directly aimed at the virus, so we get resistant to them. That is why non-responders need to think very carefully before retreating with PIs. They might need to add more than a PI to the mix in a future tx. So if we are non-responders and perhaps even just partial responders, maybe we should wait for other PIs and polymerase inhibitors to be approved. Worth thinking about.
As to "the first time you treat are the best results", I have wondered about this also. I think it might be that having relapsed or non-responded once, you know that you are not in the percentage easily cured. That is all.
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