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What's more likely False Negative PCR or False Positive?

If i got two PCR culture tests and one was negative and one was positive but by many doctors they said I'm at low risk of having it and they didn't think i had it (for a multitude of different reasons) despite the positive test result, which one would be more likely? Thank you for anyone that can help me out!
9 Responses
Avatar universal
Please give full details of what tests you had done, what was found to be positive or negative and particuarly how many swabs were taken and from where?
Avatar universal
I had a pcr swab test of lesions on my genitals (which didnt look like lesions and the nurse said he didnt think it was herpes at all) i had them for a while before i actually got them checked ie 4 days say. It felt really rushed and they didnt use two swabs only one on several areas this came back positive (i have suspicion its wrong because every doctor says i have a really low risk of it. In addition my clinic number was wrong at first and they gave me someone elses and then on the system it was showing me going into the clinic on a day i didnt. Then when i got another one a week later it was fresh and open and new like an ulcer and i went to a different london hospital and they did a lesion pcr on the one lesion with two swabs and this came back negative. Thank you for helping me
Avatar universal
I think a blood test for confirmation 12 weeks after the lesions appeared might shed more light on the issue.
Avatar universal
I would have one but in the uk they dont seem to do them unless you are pregnant and are at high risk of obtaining hsv or transmitting it. Out of the information i have given what do you think? Also i have had oral coldsores before and when stressing out about whether or not this is genital hsv2 (and i mean really stressing, i got a coldsore) so i should have had even more protection against it. Not to mention i have only had sex once with a virgin and that was protected sex and that was 8 months ago yet symptoms have only just started. I didnt really feel much pain only if i pressed the affected areas, i had no urine pain, no clusters just individual areas, no scabs particularly just healed and then left scars. So what do you think? Also another question, since PCR lesion testing is an NAAT test and tests DNA would it pick it up if i wasnt viral shedding? Because it tests the dna and it would be in my dna so it should pick it up correct?
Avatar universal
I would have one but in the uk they dont seem to do them unless you are pregnant and are at high risk of obtaining hsv or transmitting it. Out of the information i have given what do you think? Also i have had oral coldsores before and when stressing out about whether or not this is genital hsv2 (and i mean really stressing, i got a coldsore) so i should have had even more protection against it. I also had protected sex with a virgin and it was the first time for me aswell. Also there wasnt clusters, they left scars, it appeared 8 months after sexual intercourse, it wasnt no where near as painful as people describe only itchy. What do ya think?
Avatar universal
PCR testing is type specific. What was detected, HSV1 or HSV2?

If you have only had sex (of any kind) with a virgin then it is not feasible for you to have been infected with HSV2.

Usually you would expect to have symptoms within a week of being infected. 8 months later suggests another cause entirely.

Are you saying you have had no sex in the 8 months through to the blisters appearing (sex of any kind, protected, oral etc.)?
Avatar universal
If was for Hsv2 genitally, im telling the truth i was a virgin and i believe she wad too. No symptoms happened till 8 months. I have had previous oral cold sores before and stressing out about genital herpes the past month has given me one. She was first person i had sex with and Since having sex (protected) with her i had not had sex with anyone since not oral not anything. See this is why i think the first positive pcr is wrong and my negative pcr is true - what dya reckon?
Avatar universal
I think enough time has passed for you to seek a blood test. Type specific for IgG HSV1 and IgG HSV2.

in the UK you may need to obtain this privately.
Avatar universal
I don't believe i have it. Even privately i think its going to be difficult as im 18. I'm not even 100 percent that if i checked my medical records that it would be on there because of the first test i had they gave me someone elses clinic number and then couldnt find my results for 20 minutes and then their computer said i had checked in on a day i hadnt.
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