I had my hysterectomy more than 3 years ago. I have been on a minimal 1/2 pill dose of Premarin and it worked wonderfully. My doctor had be go off of the premarin 4 months ago. (Note: I took the 1/2 pill with great caution as my mom took premarin for many years and ended up with breast cancer which eventually took her life 5 years ago). I have been tortured since stopping my premarin regime. I don't think I have had a full nights sleep since - in fact last evening the first wake up was at 3:38 and then I had 5 more flashes before I finally got out of bed and started my day with more flashes. My gen practioner has suggested prozac ... sorry but that seems a bit severe. Any suggestions? I truly need to get some sleep!