I am sorry your wife's gyn removed all her parts. Mine were also removed (needlessly since all that needed to be removed was an ovarian cyst). For me, the effects were severe in every way. I became suicidal and aged dramatically overnight (hair, skin, vision, muscle mass) and couldn't function... couldn't concentrate, think logically, remember anything, couldn't sleep, etc. Estrogen was a huge help for me.
Was she possibly on too little or too much estrogen or a delivery route that didn't suit her? The patch was miserable for me. I am now on the estradiol pill.
If estrogen doesn't help her, there are many choices of anti-depressants or she could try a supplement such as St. John's wort or 5-HTP. Those are the ones that come to mind although I suspect there are others.
I wish you both the best with this.