I am 45 year old female. In Aug08 I had bout with what I thought was food poisoning, or virus, I noticed inflamation in my hands - lasted a couple of weeks. Then I noticed that my sleep was being interupted by a lead weight feeling in my bladder - intermitent. My fist thought was that this issue with my bladder had something to do with incontinence. In Oct08 I went to see a Gyno-Urologist for a bladder test, with the possibility of getting a TVT sling. They did a cystostomy. Two weeks after bladder test I felt like I was coming down with UTI, with discomfort in my bladder - urgency and heavy feeling. I had a couple of dip tests done, they were negative. While waiting for a culture, I was prescribed 6 days of Cipro. At first symtoms cleared. I thought UTI was gone, however on the 5th day of Cipro the symptoms returned. The culture came back contaminated with low levels of mixed gram positive bacteria. My doctor said it was likely I had inflamation in my bladder, but no infection. I started drinking lots of water. Somedays my symptoms would lighten, but really no improvement. I tried Detrol, under the theory that I had an overactive bladder. This did not help. By mid Dec08, my symptoms had worsened, now my Urethra was involved - it wasn't burning, but it felt like it was throbbing with sprayed urine stream. I was prescribed 3 weeks of Macrobid and Phenzo. At first this did not appear to be helping, but then by the end of the 2nd week I was starting to feel better, and by the end of the 3rd week, I felt cured. For almost 2 months I was symptom free, then in March09 the symptoms creept back in. I was prescribed 1 week of Macrobid, this did not help. My symptoms are urgency with some bladder and Urethra discomfort and pain. I can ignore it during the day, but my sleep is disrupted by bladder discomfort. Another urine culture - again, contaminated with low levels gram positive bacteria. My GP think I have IC - I hope it is UTI? What should I do?