zoloft clearly not doing its job!!

[medfundhelp]

is it possable that with stage4 kidney failure(26% function) my zoloft(100mg/day in the morning) will not work as well or at all?

[Paderla Anitha, DNB]

Hello and hope you are doing well.

It means that zoloft absorption and its therapeutic levels in the blood will be achieved for kidney disease patients. It will act due to the adequate therapeutic levels. But since there is a problem with excretion, the dosage may need to be adjusted to lower levels.

Hope this helped and do keep us posted.

[medfundhelp]

Hi Paderla, thank you for replying.  i am not doing well at all... i understand the 1st part, but its this part "Otherwise the absorption and bioavailability are normal for patients with kidney failure" that i am not getting at all.  Can you please tell me?

thanks,
medfundhelp

[Paderla Anitha, DNB]

Hello and hope you are doing well.

Zoloft is excreted in the urine and feces, so if there is kidney failure it may need dose adjustment. Otherwise the absorption and bioavailability are normal for patients with kidney failure.  

Hope this helped and do keep us posted.