CAN ANYONE RELATE?? 27/f LOW WBC, ETC

[yen492]

My symptoms started in June with horrible chest pain, over the past two months they have progressed into much more, including....upper abdominal pain,night sweats, loose stool, horrible bone pain, weight loss (13lbs,) fatique, blurred vision, horrible shooting pains in my head, & of course the horrific chest pain still. NOBODY can seem to diagnose me. The first doctor I had seen on June 24th put me on Steroids for 5 days 40mg a day bc he seemed to think I had a viral infection, I ended the prescription on July 1st. All the steroids seemed to do was artificially raise my counts temporarily and lead me to getting a rare staph infection called staphylococcus lugdunensis in my right inguinal lymph node 2 weeks after being on them. Now having the Staph infection in my bloodstream  it's causing more misdiagnoses, as my whole CBC is in normal range due to the infection except an RDW of 15.2 (H)

These were my lab results on June 24th  
WBC 2.6 (L)
PLATELET 142 (L)
MONO% 19.6 (H)
ABSOLUTE LYMPH 0.8 (L)
ABSOLUTE NEUT 1.3 (L)
SGOT 49 (H)
SGPT 54 (BORDERLINE HIGH)
C-REACTIVE PROTEIN 19.9 (H)

I also had a bone marrow biopsy which reads....
Mildly Hypocellular 60% with trilineage hematopoiesis
Slightly decreased erythropoiesis and granulopoiesis
Polytypic B Cell & T Cell population

Obviously this is abnormal my doctor told me to just "watch it"

[Ken_PA]

How did that work?

Btw, some lymphomas have a family connection but others don't, so you can find out which type and see if there is a genetic connection.

(P.S. I'd meant that you had some immune irregularities for 4 years. Everything might be connected.)

[yen492]

Hi Ken,
Thank you for your reply. My symptoms have been going on for about 3 months now, not four years! Sorry for the confusion. I am actually going to see an infectious disease doctor tmrw. But for the time being, any suggestions you have that can bring me in the right direction would be greatly appreciated. My distant relative (2nd cousin) had Lymphoma years ago, but that is the only relative I know of having any immune conditions. I had a chest CT done my first ER visit only because I had an elevated D-dimer, it came back negative showing no blood clots. My concern is that is was the only thing the pathologist was looking for. My doctors seem to think otherwise, and had there of been any enlarged lymph nodes it would have been stated. ?? Talk to you soon. Thanks again!

[Ken_PA]

Hi, I don't see why a doc would prescribe steroids for a viral infection.

I do see that some of your symptoms have been going on for a while with you (4 years). If it were a lymphoma, it *probably* would have been very apparent by now. Your marrow having polytypic and not monotypic cells says it's probably not cancer in there. Nothing is certain. But something in the marrow is causing you to produce fewer blood cells, maybe some virus which is causing all your other symptoms and which your monocytes are fighting. I'd ask on an infectious disease group. The bone pain stands out, though it doesn't seem to be Multiple Myeloma.

Or maybe you have some autoimmunity or some autoinflammatory condition. Do you have relatives with any unusual immune conditions?

Btw, corticosteroids will raise WBC as cells (which are normally compartmented on standby duty in the marrow and spleen) get released into the circulation. But the cells also get their activity reduced, which is what makes you vulnerable to infections on steroids.