PLSE , PLSE HELP US

[gudy]

my uncle 49yrs old  , large tumor in his stomach, he was diagnosed as DLBCL -CD 20+VE , bone marrow was positive,took chemo R-CHOP ON (RCC INDIA TRM
0 2010.  he had local reocurance and took 2nd line chemo with R-DHAP.he progressed again, so he was put on T.Endoxan and Prednisolene.

clinical findings.

general condition  ;     pallor+
                                   No SCLNE.

pulse;                       72/min
cardio v sys;     huge retroperitoneal  mass +
moderate Asitis +.
diagnosis;  NHL- Retroperitoneum (dlbcl- high grade   progressive disease.

CAN HE BE CURED , OR can OPERATE AND CAN REMOVE THAT MASS ,IF THERE IS ANY IDEA PLEASE LET ME KNOW , WE  HAVE NO IDEA WHAT TO DO?  PLSE HELP US       .

[Ken_PA]

Hi, you can also look into radiation as therapy - which would mean total body irradiation as a last ditch. Good luck.

[gudy]

thanks ,Ken for your comments,

[Ken_PA]

Hello. I'm sorry that you have such bad news.  Here are some guesses: I'd assume that the tumor is not operable because it is near or around other structures like organs or blood vessels. On the other hand, if it is not causing any imminent danger, there is no real reason to remove it - apparently the cancer is spread throughout anyway. Besides, when a patient is in bad shape and weakened, that's not a time to have surgery.

You say he is CD20 negative? Then unfortunately that means rituximab would not be used.

I would keep an eye on how much the ascites worsens. That might be the worst danger to him.

In the US, when nothing else is available a patient can look to "clinical trials" of new, experimental drugs. I don't know if that would be available near you.