I'm glad to be of help. It's important to understand what's going on.
You can get a copy of tests from your doc via email, fax or mail - if you can't get that online. In some doctor offices they even have a CBC machine right there and so you can get a copy immediately - then right away look to see if your platelets and/or neutrophils have gone down any because that would probably be a good sign.
Okay, there is a lot to go through here. Unfortunately, your situation is very complicated and so it's almost too much to absorb. But let's not jump to thinking about having leukemia right off the bat.
The most important thing to start off with is the *thrombocytosis*, which is having too many platelets. That changes everything. That is also much less frequent than having low platelets.
As a possible cause, there is "reactive thrombocytosis". That can come from an infection and inflammation (which also causes a high CRP). It can come from low iron. There are also other causes, including blood cancers - which is probably why you were tested for CML.
Another cause is "essential thrombocytosis", which I think would be more associated with super high platelet counts. So we need to know your CBC results.
There is also the neutrophilia (I'm guessing you made a typo above and left out the "ia"). We need to know if you neutrophil count is normal high (as in an infection) or super high. So we need to know your CBC results for that, too.
I suppose that's enough for now. My guess is that you had some infection, which resulted in discovering the BCR-ABL1 gene. But the BCR-ABL1 gene doesn't necessarily mean you have leukemia, which is supported by your (mostly) negative bone marrow test and lack or abnormal circulating blood cells.
The CT is probably to rule out the presence of enlarged lymph nodes (ALL) or some mass (CML), which they have to do because you have the BCR-ABL1 gene. Hopefully, your scan is clear and then you move on to discovering what you do have and why.
Then again, enlarged nodes jp to a certain size can be from an infection. As you can see, it's not going to be simple. But still, all of this is much better than having a firm diagnosis of leukemia. So there is good cause to keep your hopes up.
Hi, I'd assume things went like this so far:
- weakness/fatigue led to testing for anemia
- some iron test was low, so a more precise test (TIBC) was ordered
- something else had to be discovered next, in order to justify the very involved BCR-ABL1 test? Enlarged spleen? Family history? Abnormal blood smear?
- with the positive BCR-ABL1 test, the suspected cause of low platelets was marrow suppression from CML or ALL
- but then the marrow biopsy showed nothing bad inside
So now you need an alternate, plausible cause...
What were your CBCs like?
Since abnormal lymphocytes are a possibility, has your doctor mentioned "secondary ITP"?
That's where bad lymphocytes cause destruction of the platelets by the immune system. Do you have a family history of immune system disorders?
How low were your platelets? How high was your WBC?
Being hopeful, here's a case where someone had repeated positive tests like yours over a period of time but never developed leukemia:
https://www.hindawi.com/journals/crim/2010/939706/
"Asymptomatic healthy persons with xxxxxxx chromosomal translocation are fairly common. Although there is no long-term followup for this group of patients, given the rarity of CML in general population, one could extrapolate that only small portion of this population would develop CML."
I don't know if that's your exact same test.