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Elevated GGT and LDH???

My husband took dacarbazine for his melanoma that spread to his liver.  His GGT shot up to 400 and LDH shot up to 2000, everything else stayed in the normal range.  His oncologist said nothing of it, but I am worried the dacarbazine is killing his liver.  He is very tired and weak and has lost a bunch of weight.  We went to watch our god-son scrimmage and he had to go back and sit in the car.  What does it mean??
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