Before Christmas I went to my doctor complaining of fatigue. He did a full blood count and most came back normal except that I had very low vitamin D (33.3mol/L) and high Vitamin B12 (856ng/L). So he's prescribed me 20,000IU cholecalciferol capsules to take (twice a week for 6 weeks).
Liver function tests showed up the following:
High GGT - 89 iu/L (normal range 2-50);
High ALT - 66iu/L (normal range 0-40);
Normal AST - 37iu/L
Normal ALP - 36iu/L
Normal Albumin - 41/L
Normal Bilirubin - 12umol/L
On the basis of these results he sent me for an ultrasound scan of the liver, which showed up some fatty deposits. Due to this, he is referring me to a liver specialist.
I am only 29 years old and I overweight (BMI 30) but am losing weight (down from 250lb to 210lb in 12 months) by eating less unhealthy food and cutting portion sizes.
I also have a 5cm hiatus hernia, for which I have been taking 20mg omeprazole daily for almost 3 years (which I am unhappy about, as I didn't think PPI's were meant to be taken long term). Since the liver test results, I have stopped taking this since I read it can cause elevated liver enzymes, I am taking 75mg Zantac daily instead. I do get abdominal pain, but it's difficult to tell if it's being caused by the hernia or not.
I am changing my diet to suit. I've also started taking 360mg Milk Thistle, 500mg Choline, 1000mg Taurine supplements daily, in addition to my normal multivitamin and omega 3 fish oil.
My questions are -
1. How severe do you think the damage is, based on the above LFT figures?
2. Do you think the long term omeprazole use could have caused the elevated liver enzymes?
3. Do you think the low vitamin D & high B12 are related to liver function?
Many thanks, I look forward to your reply.