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8170270 tn?1413845335

Questions about lab results

Hi again, I'm hoping to get some help on understanding what my most recent labs could be indicating. I've listed the results that were marked too high or too low below. Thank you in advance I appreciate the help.

I was referred to a GI after my ALK PHOS AST and ALT were shown steadily rising over the course of a few months along with complaints of symptoms including: extreme fatigue, severe itching, weakness, bloating, almost constant nausea, loss of appetite etc. I had an ultrasound for my upper right abdomen which came back normal but the GI has scheduled an MRI and said getting a biopsy is a possibility based on the next results.

I have Hashimoto's and I have tested negative for: Celiac Disease, Wilson's Disease, Hep C, autoimmune hepatitis, RA, Lupus, Lyme disease.

ALK PHOS 173  H  (35-105)
AST 102  H  (0-32)
ALT  154  H  (0-33)

GGT 291  H  (6-42)

A1AT  81.0 L (90-200)

ALK PHOS ISOENZ  179  H  (39-117)


Immunoglobulin's all came back normal along with PT/ratio/INR, TSH, ANCA, CMP, Intestinal, liver and bone fraction.
4 Responses
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8170270 tn?1413845335
Thanks so much for your help I appreciate it.
Helpful - 0
Avatar universal
Yes, if you were dealing with alpha-1 antitrypsin deficiency, your MRI as would appear normal until advanced stages. But that doesn't mean it's a confirmation either. Will be interesting news from your doctor next visit for sure. Good luck is getting things nailed down.
Helpful - 0
8170270 tn?1413845335
Thank you for the response. My MRI came back normal and my GI said she didn't feel comfortable discussing the possibilities over the phone. Would any of the conditions you mentioned let me have a normal MRI?
Helpful - 0
Avatar universal
Sorry I've been recently MIA due to doctor issues. Your basic liver numbers seem to be pointing to combined hepatocellular/biliary issue. And given the A1AT levels, you might be dealing with an alpha-1 antitrypsin deficiency problem. It is a inherited genetic diesease with mutations in the SERPINA1 gene that leads to the alpha-1 antitrypsin deficiency.

I don't know much beyond that but this should be diagnosable with both of your blood work and biopsy. And it fits the combined diagnostic workup you've been getting so far but it's just hard to pin down sometimes. It was something they specifically looked for in my liver biopsies, as a co-condition.

Keep us posted with your latest diagnostic numbers, it's a challenging diagnosis for sure.
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