Long chemical names deleted. This is the simple version. The full article is here:
The MTHFR A1298C mutation affects an enzyme that inhibits the utilization of something that inhibits an important chemical, which is a cofactor in neurotransmitter production, including serotonin, dopamine, melatonin, epinephrine, and norepinephrine.
It also plays a role in the production of nitric oxide. If you have the MTHFR A1298C mutation, you may be deficient in BH4, which may cause psychological or neurological problems, as well as cardiovascular disease.
Some researchers feel that having both variants positive is much worse.
A1298C, has been studied a little bit less than the C677T variant but can cause problems too, although it seems that it only does that when it comes along with the C677T variant. (Conflicting opinions are present. And I don't know nearly enough to separate wheat from chaff in this field.)
Caps for emphasis only.
BUT THIS IS SOMETHING YOU DEFINITELY HAVE TO DISCUSS WITH YOUR DOCTOR OR A GENETICS COUNSELOR.
You can go to Genetic Genie and upload the results and a full explanation will come out. I know it works for 23andme results. Not sure about other labs.
23andme was co-founded by Anne Wojcicki.
Anne Wojcicki is married to Sergey Brin, co-founder of Google.
He underwrote the cost of the company's Parkinson's disease genetics initiative to provide free testing for people suffering from the condition. His mother suffers from Parkinson's.
23andme reduced the price of its product, which was originally priced at $999, from $299 to $99 in an effort to increase its customer base from 180,000 to one million.