Aa
Aa
A
A
A
Close
4939681 tn?1361299299

Anyone good with understanding MTHFR results?

Single mutation (A1298C) identified.  The lab's following explanation of what that means is like Chinese to me.  Complete nonsense to someone who can't process info clearly:(. Could anyone explain what MTHFR tests are for and what possible results mean in LAYMAN'S TERMS for me please.  It appears it was only tested for A1298C and C677T (the latter was negative).
3 Responses
Avatar universal
Long chemical names deleted. This is the simple version. The full article is here:
http://www.mthfra1298c.com/

The MTHFR A1298C mutation affects an enzyme that inhibits the utilization of something that inhibits an important chemical, which is a cofactor in neurotransmitter production, including serotonin, dopamine, melatonin, epinephrine, and norepinephrine.

It also plays a role in the production of nitric oxide. If you have the MTHFR A1298C mutation, you may be deficient in BH4, which may cause psychological or neurological problems, as well as cardiovascular disease.

Some researchers feel that having both variants positive is much worse.

A1298C, has been studied a little bit less than the C677T variant but  can cause problems too, although it seems that it only does that when it comes along with the C677T variant. (Conflicting opinions are present. And I don't know nearly enough to separate wheat from chaff in this field.)

Caps for emphasis only.
BUT THIS IS SOMETHING YOU DEFINITELY HAVE TO DISCUSS WITH YOUR DOCTOR OR A GENETICS COUNSELOR.
1763947 tn?1334055319
You can go to Genetic Genie and upload the results and a full explanation will come out. I know it works for 23andme results. Not sure about other labs.
Avatar universal
Factoids:
23andme was co-founded by Anne Wojcicki.
Anne Wojcicki is married to Sergey Brin, co-founder of Google.
He underwrote the cost of the company's Parkinson's disease             genetics initiative to provide free testing for people suffering from the condition. His mother suffers from Parkinson's.

23andme reduced the price of its product, which was originally priced at $999, from $299 to $99 in an effort to increase its customer base from 180,000 to one million.
Have an Answer?

You are reading content posted in the Lyme Disease Community

Top Infectious Diseases Answerers
1415174 tn?1453243103
CA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Popular Resources
Fearing autism, many parents aren't vaccinating their kids. Can doctors reverse this dangerous trend?
Can HIV be transmitted through this sexual activity? Dr. Jose Gonzalez-Garcia answers this commonly-asked question.
A breakthrough study discovers how to reduce risk of HIV transmission by 95 percent.
Dr. Jose Gonzalez-Garcia provides insight to the most commonly asked question about the transfer of HIV between partners.
Before your drop a dime at the pharmacy, find out if these popular cold and flu home remedies are a wonder or a waste
Fend off colds and the flu with these disease-fighting foods