It sounds like your doc is trying to be very thorough, which is good, but may not have a progressive view of Lyme. I'm not medically trained, so I'm guessing this because he is covering all the bases with the testing, but is not pursuing what may be Lyme, which is a fairly common infection these days.
For example, band 23 on a Lyme test will not light up positive except in the presence of Lyme bacteria. It is one of only a few bands on the tests that have that quality. That your doc says it's not enough to qualify as a Lyme infection indicates that he is not a progressive thinker about Lyme disease. There is much research going on and there are advances in diagnosis and treatment, but many of them are ignored by so-called mainstream medicine, for political reasons. If you go to ILADS [dot] org, under the tab 'about Lyme' and read Burrascano's 'Diagnostic Hints ...' you'll see how an LLMD (a Lyme specialist) thinks.
There are possible co-infections other than the three you list, but your doc may not have tested you for them, based on your symptoms. An LLMD could explore that with you.
I have heard from other Lyme patients that lumps under the skin are not uncommon, and they come and go. I don't know what they are inside, but odd swellings are not unusual in Lyme.
Lyme can and does mess with the whole endocrine system, including thyroid. It happened to me. I got some thyroid nodules, which in an abundance of caution, my LLMD had tested by FNAB [fine needle aspiration biopsy] to be sure there was not a concurrent cancer going on, and it was all negative. So don't automatically assume you have cancer, okay? Your doc is just being careful, which is good.
You may have or have had EBV, which is a pretty common virus causing infectious mononucleosis. Thus the positive result on that test could indicate a current or recent EBV infection.
C-reactive protein is high when you have inflammation, and that can happen in Lyme and other things too, so I wouldn't worry about it too much. Many of us with Lyme have inflammation of various kinds, lumps and swellings in joints and elsewhere.
To answer your questions:
"Would Lyme cause those kind of results or could Lyme cause cancer?" Yes, I think Lyme could cause those test results, and no, I don't think Lyme can cause cancer. It's a bacterial infection. I've never read that cancer is caused by bacteria.
"What does the protein p23 have to do with cancer?" Nothing that I know of.
So in your situation, I'd wait till the tests come back, get copies of ALL your test results, and find a Lyme specialist for a second opinion, but you don't necessarily need to tell your current doc you are going to do that. NonLLMDs often don't react well knowing that a patient is going to see an LLMD, because they are often considered quacks. Some of them may be, but that's true of 'regular' docs too.
Best wishes --
I had lyme first undiagnosed, and finally got so sick, read about lyme disease. Told Doc I thought I had lyme or cancer, then she found breast lump
then I was diagnosed with lyme and cancer. I was on iv antibiotics for a long time, and had to do alternative cancer treatment due to how sick I was. I wanted the tumors biopsied for spirochete, mycobacteria, fungi, and bunch of other stuff but they refused. I have since learned that intracellular pathogens cause cancer. ie, infections like viruses, fungi, mycoplasms, bacterias, can get in to the cells, and make them form cancers. I have read alot about this stuff. rife machines, IV antibiotics, and lots of other treatments help lyme, but I dont feel completely cured yet. I feel like I have lost my soul. I am not the person I used to be. I am a shell..... Seems to attack your joy, complex thinking, creativity, etc. along with the physically disabling joint, muscle, fatigue issues, etc. Lyme is the great masquerador, many diseases are undiagnosed lymes. guillon berrae, lupus, Multiple Sclerosid, fibromyalgia, rhumatoid arthritis, myasthenia gravis, parkinsons disease, alzheimers, and many many more. Do your research. What these all have in common is no one really knows exactly what causes them. They put all your symptoms in a basket and then see which disease name you fit closest too. What a CROCK. They keep coming up with new diseases hmmmmmmmm.
I was diagnosed with everything, Lupus, vasulitits, hashimotos. my c -reaction protein was high, EBV, and many more but my Lyme brain, I have lesions on my brain, keep me from remembering at this minute but I agree with Jackie, I have never heard of it causing cancer. It can "pretend" to be all these other illnesses though so having someone (an LLMD) who really understands this is the key in guiding your way through it. I do have swollen lymph nodes all over my body which hurts but I heard this is not uncommon.
Odd, this just popped up on my iPhone. I understand this was posted years ago but I'm replying in case anyone still might see this. In 2010 I broke by tibula and fibula that needed hardware to set, eight months later my "perfectly healing" leg accessed. They removed the hardware from infected side and found serratia marcences (gram negative bacteria) got into my bone. The surgon gave me 4-6 weeks oral Cipro. Soon after I developed chronic fatigue, pain and cognitive issues. In May 2013 I had remaining hardware removed thinking I would improve, but I got worse. Blood work suggested infection but they could not source. January 2014 scans showed tumors, masses in lungs, enlarged adrenal glad with mass/cyst and fibroids in uterus (zero history and post menopause). Reports said appeared infectious/inflammatory. Tested for Lyme's but only have 2 of required 5 bands so "negative". Biopsies in November 2014 said NSCLC in lungs and lymph nodes. I was and remain asymptomatic for cancer. February 3, 2015 2nd opinion said Stage 4. Did "only option" of chemo May-June with little results. November it progressed but looked "infectious". Biopsies found Histiocytosis X (LCH). July 2016 3rd oncologist said everything was misinterpreted but scans did not show LCH in bones and it had spread to my heart so he said it must all be cancer. IMO heart cancer is ridiculously rare AND I found subgroup of Histiocytosis/LCH ECD disease and the only one that affects the heart. I haven't been able to get myself to see another "specialist" since but I found doctor at Hopkins that sees patients with ECD and hope to see him soon. I believe first recommended treatment of daily radiation and weekly chemo would have kllled me and they never would have found LCH. Every medical professional has said I should have had 4-6 weeks IV antibiotics followed by 6 months to a year of oral after my leg abcessed in 2011, and that's what made me sick. I don't believe Histiocytosis is rare I think it's ignored. My PCP has let me take a combo of Bactrim and prednisone since I had a sinus/bronchial infection last July. I have IMPROVED and take that combo every 2-6 weeks for approx 10 days (prednisone is recommended for LCH). I believe Histiocytosis/LCH/ECD caused my tumors, lesions, masses and cysts. It's been next to impossible to get a doctor to consider anything other than cancer after I was "branded" with it. I also believe it could be Lyme's related because I had a ton of confirmed deer ticks since living by woods since 2005. I also believe only 2 bands should not be considered "negative" by the CDC. Whatever I have I do not believe it's cancer because I remain asymptomatic for it. Please try to get tested for LCH/ECD. Best of luck to everyone!