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My Test Results from CD57 and Igenex
I got my test results back. My LLMD tested me for CD57, C4a, and C3a. MyCD57 was at 26 which he said is poor and indicates the chronic Lyme. I had my first tick bite 20 years ago and it is apprent I have been fighting off an infection for a long time based on all my results. My C4a is more than 2x times higher than what it should be at 6111. My C3a was a normal level.
Has anyone else had these kinds of tests?
My Igenex Western Blot would be considered negative by the CDC. Only 2 bands came back positve and I was wondering if anyone is familiar with them. They are:
31 kDa -Indeterminate
41 kDa -Positive
I had more RA test done too and mercury level testing. All of these came back negative so he is sure I don't have RA now or any other problems. However my Thyroid is not doing well too so I will be on Armour. The LLMD believes I may have Hashimotos Thyroiditis to top it all off and there is a lot of evidence of those having Lymes and thyroid diseases at the same time. So I will need more tests again in a month. That's a good thing I don't have RA considering I want to go back to archaeology, dancing, and want more children and if I can just get through this Lymes I would be so active again.
Has anyone else had these kinds of tests?
My Igenex Western Blot would be considered negative by the CDC. Only 2 bands came back positve and I was wondering if anyone is familiar with them. They are:
31 kDa -Indeterminate
41 kDa -Positive
I had more RA test done too and mercury level testing. All of these came back negative so he is sure I don't have RA now or any other problems. However my Thyroid is not doing well too so I will be on Armour. The LLMD believes I may have Hashimotos Thyroiditis to top it all off and there is a lot of evidence of those having Lymes and thyroid diseases at the same time. So I will need more tests again in a month. That's a good thing I don't have RA considering I want to go back to archaeology, dancing, and want more children and if I can just get through this Lymes I would be so active again.
No tests are 100%, but on a normal range of 60 to 360, if your result is 39, then yes, you are very low, and according to Stricker's theory, that is a positive indicator that you have Lyme.
Hi
Sorry I don't really understand that....
Does a 39 mean I could have lyme or would have lyme.
Another lady here today told me not to rely on the cd57 australian testing as its not reliable.
Now I am even more confused.
To get the test done overseas at ignex is going to cost myself $1200 and for my daughter also.
I don't know if its even worth having it, as she also said its not 100%
Sorry I don't really understand that....
Does a 39 mean I could have lyme or would have lyme.
Another lady here today told me not to rely on the cd57 australian testing as its not reliable.
Now I am even more confused.
To get the test done overseas at ignex is going to cost myself $1200 and for my daughter also.
I don't know if its even worth having it, as she also said its not 100%
Welcome to MedHelp Lyme -- I hope we can give you some useful information, tho of course no one here is medically trained as far as I know.
Here is the summary of a medical article published by Dr Stricker ten years ago, with his views on CD57 being low in those with longterm Lyme (and indicates that a 'normal' range for CD57 is 60-360 (I've noted that part inside ***asterisks*** below):
======================================================
Decreased CD57 lymphocyte subset in patients with chronic Lyme disease.
Stricker RB, Winger EE.
Department of Medicine, California Pacific Medical Center, 450 Sutter Street, Suite 1504, San Francisco, CA 94108, USA. ***@****
Abstract
BACKGROUND: Chronic Lyme disease (LD) is a debilitating illness caused by tickborne infection with the spirochete Borrelia burgdorferi. Although immunologic abnormalities appear to play a role in this disease, specific immunologic markers of chronic LD have not been identified.
METHODS: We evaluated 73 patients with chronic LD for lymphocyte subset abnormalities using flow cytometry. Of these, 53 patients had predominant musculoskeletal symptoms, while 20 patients had predominant neurologic symptoms. The estimated duration of infection ranged from 3 months to 15 years, and all patients had positive serologic tests for B. burgdorferi. Ten patients with acute LD (infection less than 1 month) and 22 patients with acquired immunodeficiency syndrome (AIDS) served as disease controls.
RESULTS: All 31 chronic LD patients who were tested prior to antibiotic treatment had significantly decreased CD57 lymphocyte counts (mean, 30+/-16 cells per microl; ***normal, 60-360 cells per microl***, P<0.001). Nineteen of 37 patients (51%) who were tested after initiating antibiotic therapy had decreased CD57 levels (mean, 66+/-39 cells per microl), and all five patients tested after completing antibiotic treatment had normal CD57 counts (mean, 173+/-98 cells per microl). In contrast, all 10 patients with acute LD and 82% of AIDS patients had normal CD57 levels, and the difference between these groups and the pre-treatment patients with chronic LD was significant (P<0.001). Patients with chronic LD and predominant neurologic symptoms had significantly lower mean CD57 levels than patients with predominant musculoskeletal symptoms (30+/-21 vs. 58+/-37 cells per microl, P=0.002). CD57 levels increased in chronic LD patients whose symptoms improved, while patients with refractory disease had persistently low CD57 counts.
CONCLUSIONS: A decrease in the CD57 lymphocyte subset may be an important marker of chronic LD. Changes in the CD57 subset may be useful to monitor the response to therapy in this disease.
PMID: 11222912 [PubMed - indexed for MEDLINE]
=============================================================
As to your test showing a positive band 39, that particular marker on a Lyme test is specific to Lyme bacteria, meaning that no other bacteria would show up positive on the test except for Lyme. Some MDs require more bands and a certain level of strength in the band.
We've had some others post here who are from Australia/New Zealand, you might search for them in the box up at the top.
Best wishes -- let us know if we can help further.
Here is the summary of a medical article published by Dr Stricker ten years ago, with his views on CD57 being low in those with longterm Lyme (and indicates that a 'normal' range for CD57 is 60-360 (I've noted that part inside ***asterisks*** below):
======================================================
Decreased CD57 lymphocyte subset in patients with chronic Lyme disease.
Stricker RB, Winger EE.
Department of Medicine, California Pacific Medical Center, 450 Sutter Street, Suite 1504, San Francisco, CA 94108, USA. ***@****
Abstract
BACKGROUND: Chronic Lyme disease (LD) is a debilitating illness caused by tickborne infection with the spirochete Borrelia burgdorferi. Although immunologic abnormalities appear to play a role in this disease, specific immunologic markers of chronic LD have not been identified.
METHODS: We evaluated 73 patients with chronic LD for lymphocyte subset abnormalities using flow cytometry. Of these, 53 patients had predominant musculoskeletal symptoms, while 20 patients had predominant neurologic symptoms. The estimated duration of infection ranged from 3 months to 15 years, and all patients had positive serologic tests for B. burgdorferi. Ten patients with acute LD (infection less than 1 month) and 22 patients with acquired immunodeficiency syndrome (AIDS) served as disease controls.
RESULTS: All 31 chronic LD patients who were tested prior to antibiotic treatment had significantly decreased CD57 lymphocyte counts (mean, 30+/-16 cells per microl; ***normal, 60-360 cells per microl***, P<0.001). Nineteen of 37 patients (51%) who were tested after initiating antibiotic therapy had decreased CD57 levels (mean, 66+/-39 cells per microl), and all five patients tested after completing antibiotic treatment had normal CD57 counts (mean, 173+/-98 cells per microl). In contrast, all 10 patients with acute LD and 82% of AIDS patients had normal CD57 levels, and the difference between these groups and the pre-treatment patients with chronic LD was significant (P<0.001). Patients with chronic LD and predominant neurologic symptoms had significantly lower mean CD57 levels than patients with predominant musculoskeletal symptoms (30+/-21 vs. 58+/-37 cells per microl, P=0.002). CD57 levels increased in chronic LD patients whose symptoms improved, while patients with refractory disease had persistently low CD57 counts.
CONCLUSIONS: A decrease in the CD57 lymphocyte subset may be an important marker of chronic LD. Changes in the CD57 subset may be useful to monitor the response to therapy in this disease.
PMID: 11222912 [PubMed - indexed for MEDLINE]
=============================================================
As to your test showing a positive band 39, that particular marker on a Lyme test is specific to Lyme bacteria, meaning that no other bacteria would show up positive on the test except for Lyme. Some MDs require more bands and a certain level of strength in the band.
We've had some others post here who are from Australia/New Zealand, you might search for them in the box up at the top.
Best wishes -- let us know if we can help further.
I am in Australia where they don't believe lyme is here.
Anyway I had the CD57 test done here and mine come back at 39
I just hope the testing done here is accurate, and I'm now going to have it done with ignex I think it is.
Does anyone know what a 39 is???
My Dr said it means I have lyme, I'm still a bit unsure, all this is so confusing
Anyway I had the CD57 test done here and mine come back at 39
I just hope the testing done here is accurate, and I'm now going to have it done with ignex I think it is.
Does anyone know what a 39 is???
My Dr said it means I have lyme, I'm still a bit unsure, all this is so confusing
Thank you so much for the website tip. I will go check it out. It is nice to hear from you again too.
Ok please forgive me. I am still trying to learn more about my test results and I guess I have things backwards. When I had appointment I couldn't find a babysitter and I had to bring my 15 month old DD with me so it was crazy and I was really distracted. The LLMD said that based on my CD57 being only 26 (normal =60 - 360) and my
C 3a was my inflamation rate in relation to CD57 would conclude fighting a Lyme infection. According to the CDC I am negative for Lymes on the IGM and IGG Western Blot because my results have to be positive on 5 bands. Does this sound right? Ok, so here is how it reads exactly now I can understand better.
IGM Result
39 kDa -Indeterminate
41 kDa - +++ positive
IGG result
31 kDa -Indeterminate
41 kDa - +++ positive
C 3a was my inflamation rate in relation to CD57 would conclude fighting a Lyme infection. According to the CDC I am negative for Lymes on the IGM and IGG Western Blot because my results have to be positive on 5 bands. Does this sound right? Ok, so here is how it reads exactly now I can understand better.
IGM Result
39 kDa -Indeterminate
41 kDa - +++ positive
IGG result
31 kDa -Indeterminate
41 kDa - +++ positive
My results from IgeneX were: IGG POS 30+ 31++++ 41++
IGM 30+ 31+++ 34IND 41IND 83-93IND
My results from Quest were : IGG bands 30 and 41 Reactive only.
They were both CDC neg. My CD57 was a 13.
All my other tests for everything else have been completely normal. So I'm treating for lyme, which seems like the most obvious problem and my symptoms match.
Good luck!
IGM 30+ 31+++ 34IND 41IND 83-93IND
My results from Quest were : IGG bands 30 and 41 Reactive only.
They were both CDC neg. My CD57 was a 13.
All my other tests for everything else have been completely normal. So I'm treating for lyme, which seems like the most obvious problem and my symptoms match.
Good luck!
Igengex Western blot:
IgM 41 +, IgG 41 +++ 39 +
All other bands negative. The test was CDC negative, but as noted 39 is specific to Lyme and I went through about a year of various medical testing that turned up no other determinate explanation.
My CD57 was normal, I think a little over 100.
I don't recall if I had C4a or C3a tested.
Are you going to start treatment for Lyme disease?
IgM 41 +, IgG 41 +++ 39 +
All other bands negative. The test was CDC negative, but as noted 39 is specific to Lyme and I went through about a year of various medical testing that turned up no other determinate explanation.
My CD57 was normal, I think a little over 100.
I don't recall if I had C4a or C3a tested.
Are you going to start treatment for Lyme disease?
39 is specific for Lyme
41 is common to all spirochetal bacteria, including Lyme
I printed out a list of all the possible 'hits' on this test from a website called truthaboutlymedisease [dot] com
41 is common to all spirochetal bacteria, including Lyme
I printed out a list of all the possible 'hits' on this test from a website called truthaboutlymedisease [dot] com
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