I am 27yrs old and had a total hysterectomy at 26 due to advanced stage Ovarian Cancer. I have been on Premarin first 1.25mg and now .90mg. I have been having several problems with mood swings, irritability, and weight gain. My question is, how do I know if these are side effects from Premarin or if I am going through a depression? I am in councelling, but I just started and it's not clear at this point. I am interested in taking Wellbutrin but am afraid of over-medicating myself if these are just side effects from the estrogen. Also wondering, if I lowered my dosage of Premarin to .625mg, would that help with my weight gain? Are there Dr's that specialize in hormones? Sorry for all the questions - my quality of life is so miserable right now, I think I was actually happier when I was going through chemo!