How are you? Prempro ( combination of conjugated estrogens and medroxyprogesterone) is not usually given if there is a history of heart attack, stroke, or blood clot. Since long-term intake of this medicine may also increase your risk of breast cancer, heart attack, stroke, and blood clot - it is important that you discuss with your doctor about your management plan. (ref: http://www.drugs.com/prempro.html) Aside from the clot issue, your medical history and symptoms present are important considerations also. Take care and do keep us posted.