My daughter has a history of migraine headaches associated with her period, but this time is different. The headache is milder, started with dizziness and vomiting for 2 days, but the headache has continued for 6 weeks. The dizziness was a problem for 3 weeks, then subsided but now has returned. The nausea has not led to additional vomiting, but she has trouble eating. She has lost at least 10 pounds. (I now monitor her intake to make sure she does not get dehydrated and is getting at least minimal nutrition.) After 3 weeks, we went to an ENT who examined her but found no cause. He prescribed ondansetron. Twenty minutes after taking the first one, her right leg went numb, and her foot started hurting and was ice cold. That took 2 weeks to resolve. A week after the leg went numb, her left hand and lower arm became numb and hurt, but it was not very cold. Three days later, the hand turned blue with white spots which lasted a couple of hours. That happened a second time the next day. Numbness in the hand lasted about a week. So now she just has the headache and nausea and a little dizziness. We saw a neurologist who found nothing wrong neurologically. She had an MRI and blood work for Lyme disease, mononucleosis, meningitis, and ANA (for autoimmune diseases). All were negative. Her blood count was normal and her TSH also. Her doctor is pretty much at a loss, as am I. She is 14 years old, has many allergies (to pollens and nuts), and reflux. Any ideas? Who should we see and what should we look for next? She has missed a lot of school, although most days she struggles through. She is taking no medication except Sudafed, Nasonex, and Patanase for a little congestion that her regular doctor noticed (and because allergy season is pending). When the headache gets bad, she takes two Advil.